Exploring the Relationship Between Circadian Disruption, Depression and Suicidal Ideation in People with Huntington’s Disease (Mind & Clock Study)
Objective: To examine the relationship between circadian and sleep disruptions and depressive symptoms and suicidal ideation in people with Huntington’s Disease (PwHD) using scale-based and…The Evolutionary Pathway of Cognitive Impairment in Parkinson’s Disease: A SuStaIn Study
Objective: We aim to characterize the evolution and subtypes in the cognitive impairment in Parkinson’s disease (PD). Background: Cognitive impairment (CI) is one of the…Phenotypic Evolution from Nonfluent PPA to PSP
Objective: Progressive Supranuclear Palsy (PSP) and Nonfluent Primary Progressive Aphasia (nfvPPA) are clinicopathological entities within the 4-repeat tauopathy (4R tauopathy) spectrum. Increasing evidence suggests that…Cognitive profiles in idiopathic normal pressure hydrocephalus: clinical patterns and the impact of coexisting neurodegeneration
Objective: To characterise cognitive severity and domain-specific profiles in patients with idiopathic normal pressure hydrocephalus (iNPH) and to examine the impact of coexisting neurodegeneration. Background:…Exploratory Quantitative Gait Analysis for Differentiating Parkinson’s Disease from Atypical Parkinsonian Syndromes
Objective: To compare quantitative spatiotemporal and plantar pressure gait parameters between patients with Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS) using instrumented gait analysis.…Patient Perspectives on Telemedicine and Remote Deep Brain Stimulation Programming in Parkinson’s Disease: A Questionnaire Survey
Objective: To identify unmet needs in deep brain stimulation (DBS) programming among patients with Parkinson’s disease (PD) in Japan by assessing outpatient burden and patient…An Ongoing Phase 1/2, Multi-center, Open Label Study of NouvNeu001 for the Treatment of Advanced Parkinson’s Disease
Objective: This ongoing, phase 1/2, multi-center, open label study aims to evaluate the safety, tolerability, and efficacy of NouvNeu001 (NCT#06167681) for treating mid to late-stage…Extended long-term follow-up of adaptive deep brain stimulation in Parkinson’s disease
Objective: To evaluate the extended long-term durability, programming stability, and safety of adaptive deep brain stimulation (aDBS) in people with Parkinson’s disease (PD). Background: Adaptive DBS is a recently available enhancement to continuous DBS (cDBS) that dynamically adjusts stimulation amplitude based on neural…Substantia Nigra Free-Water, Metabolic Markers, and Motor Variability in Older Adults with Diabetes
Objective: To examine whether nigral microstructural integrity measured via substantia nigra free-water MRI (FW-MRI) relates to peripheral metabolic burden and motor variability across the glycemic…Evaluating YouTube as a source of health information on Parkinson’s disease
Objective: This study aimed to evaluate the quality, reliability, and engagement characteristics of YouTube videos on Parkinson's disease using standardized assessment tools. Background: Parkinson’s disease…
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