Objective: The aim is to compare and contrast clinical profiles between UK-White Caucasian (UK-WC), UK-Asian, UK-Black African Caribbean (UK-BAC) and Mexican people with Parkinson’s disease (PD) (PwP).

Background: Ethnic differences in PD phenotype (particularly non-motor symptoms (NMS)) are poorly understood. 

Methods: Demographics as well as motor, quality of life and non-motor data assessed with validated tools were recorded, as well as nutrition habits.

Results: The mean demographics and results are shown in table 1. Demographics differ between groups with a lower mean age and mean age at onset in the Mexican group and more males in the UK-Asian group. UK-Asian and UK-BAC and Mexican PwP had higher NMSScale (NMSS) total scores compared to UK-WC PwP. The UK-BAC and UK-Asian patients reported worse quality of life compared to the UK-WC and Mexican cohort. The UK-WC PwP consumed more alcohol (mean units per day 5.3±9.4) compared to UK-Asian (2.19±4.5), UK-BAC (0.4±1.1) and Mexican PwP (0.3±0.9).

Conclusions: These preliminary findings suggest that clinical profiles may possibly differ across different ethnic groups. We are now exploring the detailed presentation as well as underlying mechanisms.

References: This study was supported by Kirby Laing foundation as well as Parkinson’s UK.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/parkinsons-disease-phenotype-across-different-ethnic-groups-comparison-of-non-motor-symptoms-in-patients-living-in-the-united-kingdom-and-mexico/