Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: The study of rhythmic neuronal activity is of great interest as they may have implications for pathophysiological mechanisms of PD. The aim of this study was to describe main patterns of rhythmic activity and investigate their possible correlation with clinical manifestations of PD.
Background: Two main hypotheses of PD pathophisiology consider changes in firing rates or firing patterns in basal ganglia to cause PD motor sympthoms. Researchers associate rhythms in teta band with tremor and beta band oscillations with rigidity and/or bradikinesia. However it is still unclear how rhythmic single unit activity provokes hypokinetic sympthoms in PD.
Methods: We performed microelectrode recording of STN unit activity in 12 PD patients undergoing DBS surgery. The specific band of neuronal oscillation was determined according to position of the peak on the power spectra, also o-scores for 3-8, 8-12, 12-20, 20-30,30-60 and 60-90 Hz were calculated. Also we have selected a group of non-rhythmic bursting neurons for parametric comparison. Bursts were detected with Poisson surprise method.
Results: Besides beta and teta oscillating single units we found neurons with alpha rhythmic activity (8-12 Hz). Alpha oclillations were registered in several patients with an early onset of disease, sometimes alpha and beta types of activity occur simultaneously. Beta oscillations tended to occur in dorsal part of STN, alpha oscillations were more stable and lack specific location in dorsoventral direction. We have found no significant differences between rhythmic and non-rhythmic activities in firing rate or inter-spike interval variance coefficient. However non-rhythmic neurons have higher percentage of spikes in a burst and lower mean ISI in a burst than rhythmic neurons.
Conclusions: Our finding suggest that rhythmic activity especcially in alpha band occured in PD patients with an early onset. Further correllation analysis of alpha activity and PD manifestation is needed for understanding pathophysiological machanisms. This work was supported within frameworks of the state task for ICP RAS 0082-2014-0001 (state registration #АААА-А17-117040610310-6), RFBR grant 18-015-00140.
To cite this abstract in AMA style:
E. Belova, A. Nezvinskiy, R. Medvednik, A. Tomskiy, A. Sedov. Patterns of rhythmic single unit activity of the subthalamic nucleus in patients with Parkinson’s disease [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/patterns-of-rhythmic-single-unit-activity-of-the-subthalamic-nucleus-in-patients-with-parkinsons-disease/. Accessed June 14, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/patterns-of-rhythmic-single-unit-activity-of-the-subthalamic-nucleus-in-patients-with-parkinsons-disease/