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Plasma levels of vitamin D in patients with Parkinson’s disease: Correlation with Mini Mental State Examination and disease duration

M. Barichella, L. Lorio, C. Bolliri, A. Giana, V. Ferri, G. Pinelli, E. Cassani, S. Caronni, C. Esposito, G. Riboldazzi, A. Maras, A. Perretti, F. Del Sorbo, P. Amadeo, R. Cilia, E. Cereda, G. Pezzoli (Milan, Italy)

Meeting: 2018 International Congress

Abstract Number: 1249

Keywords: Cognitive dysfunction, Parkinsonism

Session Information

Date: Monday, October 8, 2018

Session Title: Parkinson's Disease: Cognition

Session Time: 1:15pm-2:45pm

Location: Hall 3FG

Objective: The aim of the study is to evaluate the plasma levels of 25(OH) D in PD, correlating these values with the cognitive function and with disease duration.

Background: In recent years, attention has been paid to the role of vitamin D in Parkinson’s disease (PD), as it has been found that in the brain are present both the specific receptors for vitamin D and the enzyme 25(OH)D-1α-hydroxylase, necessary for the synthesis of the active metabolite 1,25-dihydroxyvitamin D. It has been shown that PD patients have low vitamin D levels and that a greater severity of the disease is connected with a lower serum concentration of the vitamin. The aim of the study is to evaluate the plasma levels of 25(OH) D in PD, correlating these values with the cognitive function and with disease duration.

Methods: Plasma 25(OH) D levels of PD patients recruited from throughout Italy were collected and correlated with anthropometric characteristics, Mini Mental State Examination (MMSE) and disease duration. Major exclusion criteria: age <60 yr; oral supplementation of vitamin D; disease duration < 5 yr.

Results: The aim of the study was to evaluate 500 PD; preliminary data included 120 patients, 71,6% were male (28,4% female). Mean age was 71 yr (range 60-87) and mean BMI was 26,6 kg/m² (±4,65), with no statistical difference between male and female. The mean 25(OH) D level was 18,4 ng/ml (±9,88). 93,3% of patients didn’t reach optimal levels of 32ng/ml, including 59,1% <20ng/ml and 17,5% <10ng/ml. MMSE was ≤ 20 in 5 % patients; >20 and ≤ 24 in 16 %; >24 in 79%. Mean disease duration was 10,9 ± 6,3 yr. By simple linear correlation, a significant direct association between 25(OH)D and BMI (p<0,01) and between 25(OH)D and MMSE score (p=0,01) and inverse association between 25(OH)D and disease duration (p<0,01) was observed.

Conclusions: Only 6,7% of PD reach optimal plasma levels of 25(OH)D. The higher percent of men in recruitment is due to a major incidence of supplementation in women (exclusion criteria). Low 25(OH) D levels correlated with higher BMI, worse cognitive abilities, and longer disease duration. In PD population vitamin D supplementation is needed. We are collecting nutritional data from Food Frequency Questionnaire to evaluate nutritional intake, to investigate the role of vitamin D in the risk of PD.

To cite this abstract in AMA style:

M. Barichella, L. Lorio, C. Bolliri, A. Giana, V. Ferri, G. Pinelli, E. Cassani, S. Caronni, C. Esposito, G. Riboldazzi, A. Maras, A. Perretti, F. Del Sorbo, P. Amadeo, R. Cilia, E. Cereda, G. Pezzoli. Plasma levels of vitamin D in patients with Parkinson’s disease: Correlation with Mini Mental State Examination and disease duration [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/plasma-levels-of-vitamin-d-in-patients-with-parkinsons-disease-correlation-with-mini-mental-state-examination-and-disease-duration/. Accessed May 14, 2025.
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