Objective: To evaluate the utility of universal components incorporated in the DBS screening, complemented by a wearable sensor, to predict motor outcomes and Quality of life (QoL) one year after STN DBS surgery.
Background: Standardized screening for subthalamic Deep Brain Stimulation (STN DBS) in Parkinson’s Disease (PD) patients is crucial to determine eligibility, but its utility to predict postoperative outcomes in eligible patients is inconclusive. It is unknown whether wearable data can contribute to this aim.
Method: Consecutive patients were included in the OPTIMIST cohort study from two DBS centres. Standardized assessments included a preoperative Levodopa Challenge Test (LCT), and questionnaires on QoL and non-motor symptoms including cognition, psychiatric symptoms, impulsiveness, autonomic symptoms and sleeping problems. Moreover, an ambulatory wearable sensor (Parkinson Kinetigraph (PKG)) was used. Postoperative assessments were similar and also included a Stimulation Challenge Test to determine DBS effects on motor function.
Results: Eighty-three patients were included (median (interquartile range) age 63 (56 – 68) years, 36% female). Med-OFF (Stim-OFF) motor severity deteriorated indicating disease progression, but patients significantly improved in terms of Med-ON (Stim-ON) motor function, motor fluctuations, QoL, and most non-motor domains. Motor outcomes were not predicted by preoperative tests, including covariates of either LCT or PKG. Postoperative QoL was predicted by better preoperative QoL, lower age, and more preoperative impulsiveness scores in multivariate models.
Conclusion: Data from the DBS screening including wearable data do not predict postoperative motor outcome at one year. Post-DBS QoL appears primarily driven by non-motor symptoms, rather than by motor improvement.
To cite this abstract in AMA style:
V. Geraedts, J. van Vugt, J. Marinus, R. Kuiper, H. Middelkoop, R. Zutt, N. vd Gaag, C. Hoffmann, L. Dorresteijn, J. van Hilten, MF. Contarino. Predicting motor outcome and quality of life after subthalamic DBS for Parkinson’s Disease: the role of standard screening measures and wearable-data [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/predicting-motor-outcome-and-quality-of-life-after-subthalamic-dbs-for-parkinsons-disease-the-role-of-standard-screening-measures-and-wearable-data/. Accessed June 14, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/predicting-motor-outcome-and-quality-of-life-after-subthalamic-dbs-for-parkinsons-disease-the-role-of-standard-screening-measures-and-wearable-data/