Objective: The aim of this study was to investigate prevalence and clinical characteristics of Parkinson’s disease (PD) in the Chernivtsi region of Ukraine among different gender and age groups.

Background: PD is one of the most common neurologic disorders, affecting approximately 1% of individuals older than 60 years and causing progressive disability that can be slowed down, but not halted by treatment. Many population-based studies have been performed to determine the prevalence of Parkinsonism; however, none of them was performed in Bukovina region of Ukraine.

Method: This 5-year retrospective review involved the investigation of the Register of Neurological Diseases in Chernivtsi region between the years 2013-2017. We used epidemiological and statistical methods of research.

Results: According to the Register there were registered patients with: PD – 384 patients (42.3 per 100,000 population), secondary parkinsonism – 204 (22.5), neurodegenerative disease with parkinsonism syndrome – 26 (2.9). Among patients with PD was found 46.25% men and 53.75% – women. UPDRS index increase depends on age and stage of PD. Indicator of disruption of motor aspects of daily activity in older group was 2.4 times more than in young group. Our study showed direct correlation between age and severity of clinical manifestations. 16.2% of patients were treated by dopamine receptor antagonists, 21.8% of patients – by levodopa, 13.3% – by cholinolytics drugs, 10.5% – by amantadine, 38.2% by combination of two or more antiparkinson drugs.

Conclusion: By means of our research PD is more frequent among women. The most frequent age is between 60 and 74 years old. The majority of patients in the first examination already had Hoehn and Yahr Stage 2.0. Probably this is the consequence of inadequate awareness about early peculiarities of parkinsonism among population.

References: 1. Alves G., Forsa E. B., Pedersen K. F., Dreetz Gjerstad M., Larsen J. P. Epidemiology of Parkinson’s disease. Journal of Neurology. September 2008, V. 255, Suppl. 5. 18-32. 2. Elbaz A., Carcaillon L., Kab S. Moisan F. Epidemiology of Parkinson’s disease. Revue neurologique. 172 (2016). 14- 26. 3. Jankovic J. Parkinson’s disease: clinical features and diagnosis. J.Neurol. Neurosurg. Psychiatry. 2008. 79. 368-376.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-and-clinical-characteristics-of-parkinson-disease-in-chernivtsi-region-of-ukraine/