Objective: To determine the prevalence of non-motor symptoms (NMS) and their impact on quality of life (QoL) in Mexican individuals with Parkinson’s disease (PD), aiming to guide interventions for enhancing overall QoL in this population.
Background: NMS, especially cognitive impairments, play a crucial role in the QoL of people with neurological conditions like PD. Their impact extends beyond motor symptoms, significantly affecting daily activities and interpersonal relationships, making NMS a key focus for improving overall QoL in PD patients. This study aimed to highlight the prevalence of non-motor symptoms and their correlation with QoL in Mexican PD population.
Method: The ReMePark-2 is an observational, prospective, analytical study including Mexican people living with PD (PwP). Variables collected include gender, age, education years (y), comorbidities, PD evolution in y, Hoehn-Yahr Stage (HYS), levodopa dosage, MDS-UPDRS parts 1, 2, 3 and 4, NMSS, Montreal Cognitive Assessment (MoCA) and PDQ-8i were collected. QoL, using the PDQ-8i, was correlated with each of the MDS-NMSS subdomains. Statistical analysis was conducted using Python.
Results: 1038 Mexican PwP (56.6% males; 63.5±12.8 years old) were included. Mean PD evolution 6.6±5.5 years, 77.1% in HY stages 2-3, mean levodopa dose 696.4±382.1 mg/day. Spearman’s correlations were significant between QoL and MDS-UPDRS-II (r=0.70), MDS-UPDRS-I (r=0.63), MDS-NMSS mood (r=0.55), sleep-fatigue (r=0.44), gastrointestinal (r=0.43), MDS-UPDRS-III (r=0.39), MDS-NMSS attention (r=0.37), MDS-NMSS urinary (r=0.33).
Conclusion:
Acknowledging the significance of NMS is paramount in enhancing the overall well-being and daily functioning of patients. These aspects, often overlooked during medical consultations, play a pervasive role in the patient’s experience and should not be underestimated. By recognizing and addressing NMS, healthcare professionals can contribute significantly to a more comprehensive and effective approach to patient care, ultimately leading to improved outcomes and a better QoL for PwP.
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To cite this abstract in AMA style:
A. Cervantes Arriaga, AJ. Hernandez Medrano, A. Dominguez Garcia, DP. Romero Terán, MF. Medina Perez, M. Rodriguez Violante, A. Abundes Corona, R. Solis Vivanco, AL. Guerra-Anzaldo, G. Rivera-Monroy, CF. álvarez-Hernández, RJ. Baños-Betancourt, WF. Moguel Cardín (). Prevalence of non-motor symptoms and their impact in quality of life in PD: a Mexican Registry, 2011-2019 (the ReMePark-2 study). [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/prevalence-of-non-motor-symptoms-and-their-impact-in-quality-of-life-in-pd-a-mexican-registry-2011-2019-the-remepark-2-study/. Accessed October 7, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-of-non-motor-symptoms-and-their-impact-in-quality-of-life-in-pd-a-mexican-registry-2011-2019-the-remepark-2-study/