Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To study the prevalence of Non-Motor Symptoms (NMS) in Parkinson’s disease (PD) and their impact on health-related quality of life (HRQoL).
Background: PD is a neurodegenerative disease characterized by motor features of bradykinesia, rigidity, resting tremor and postural instability. NMS are also associated with PD and have a significant impact on HRQoL than motor symptoms. They inevitably emerge through the progression of the disease and are often under-recognized and untargeted.
Methods: A cross-sectional observational study of PD patients (n=50) visiting our OPD/ as in-patients admitted in tertiary care during January 2017 to July 2017 were assessed. NMS and HRQoL are measured using NMS Scoring; PD questionnaire-39 and Hoehn & Yahr scale respectively. Motor symptoms were evaluated using SCoPA – Motor scoring scale.
Results: Of 50 study population – 32 males and 18 females with median age of 66.5years and median onset duration of 2yrs with 64.6% on treatment. Fatigue, lightheadedness, and pain were more prevalent NMS accounting about 76%, 72%, and 72% respectively. Whereas, fatigue, lost in surroundings, lack motivation and impaired concentration have shown significant impact on PDQ-39. With regression analysis, strongest predictor was NMSS score (p=0.006) with each unit increase it is associated with nearly 0.07 increase in PDQ-39 score.
Conclusions: Though motor symptoms define the disease NMS have a more significant impact on HRQoL in PD individuals as seen in our study and also on caregiver’s life. Understanding the pattern and effect of NMS is needed for treatment strategies and improve quality of life.
References: 1.Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol. 2006;5(3):235–45. 2.Bugalho P, Lampreia T, Miguel R, Mendonça MD, Caetano A, Barbosa R. Non-Motor symptoms in Portuguese Parkinson’s Disease patients: correlation and impact on Quality of Life and Activities of Daily Living. Sci Rep [Internet]. 2016;6(1):32267.
To cite this abstract in AMA style:
M. Karri, B. Ramasamy, R. Kalidoss. Prevalence of non-motor symptoms in Parkinson’s disease and its impact on quality of life in a tertiary care center in India [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/prevalence-of-non-motor-symptoms-in-parkinsons-disease-and-its-impact-on-quality-of-life-in-a-tertiary-care-center-in-india/. Accessed June 14, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-of-non-motor-symptoms-in-parkinsons-disease-and-its-impact-on-quality-of-life-in-a-tertiary-care-center-in-india/