Session Time: 1:45pm-3:15pm
Location: Agora 2 West, Level 2
Objective: Objective of our study was to evaluate protective and therapeutic activity of Cinnamaldehyde in the mouse model of Parkinson’s disease.
Background: Parkinson’s disease (PD), an age-related disorder, is accompanied by the symptoms, tremor, bradykinesia, rigidity and instability. Cinnamaldehyde (CA) is a diterpene with a wide range of anti-inflammatory, cognitive enhancer, neuroprotective effects thus may be advantageous in the treatment of neurological disease.
Method: In present study 6-hydroxydopamine (6-OHDA) model of PD mice were used. The symptoms of PD such as tremors, akinesia, rigidity, catalepsy, and vacuous chewing movements (VCMs) were evaluated. The methanolic extract of CA was administered orally at doses of 100 mg, 200 mg and 500 mg/kg body weight followed by stress. The combination of L-dopa and carbidopa was used as a standard drug. Behavioral studies such as locomotor activity and grip strength were determined, and memory test (Morris water maze) was evaluated in mice. Reactive oxygen species (ROS) generation was measured using dihydroethidium (DHE) staining. Antioxidants enzymes, neurolipofusicin, lipid peroxides and inflammatory cytokines (TNF-a, IL-1β, and IL-6) were measured in hippocampus using corresponding commercial kits were analyzed in rat model of PD.
Results: Animal exposed to stress showed significant decrease in antioxidant enzyme, glutathione and total protein. This was accompanied by simultaneous increase in lipid peroxides and neurolipofusicin level. Treatment with CA had no significant but moderate effect on antioxidant enzyme. Pretreatment with CA (200 and 500 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, and significantly increased locomotor activity and grip strength. Treatment with CA significantly reduced inflammatory cytokines , ROS level, lipid peroxides level and restored the defensive antioxidant enzymes in mice brain.
Conclusion: CA may extract appreciably improve the neuroinflammatory processes and also restore biochemical and behavioral parameters with a potential therapeutic candidate for anti-aging studies.
To cite this abstract in AMA style:S. Rajput, S. Sinha. Protective and therapeutic activity of Cinnamaldehyde in the mouse model of Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/protective-and-therapeutic-activity-of-cinnamaldehyde-in-the-mouse-model-of-parkinsons-disease/. Accessed December 5, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/protective-and-therapeutic-activity-of-cinnamaldehyde-in-the-mouse-model-of-parkinsons-disease/