Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: The aim of this study is to investigate whether depression and apathy are independently related to QoL in patients with PD. Therefore, we performed a multivariate analysis of widely used tests of numerous factors, including depression and apathy, that might affect QoL.
Background: Many nonmotor symptoms, such as apathy and depression, are observed in patients with Parkinson’s disease (PD). Depression has a major impact on health-related quality of life (QoL). However, no studies have evaluated depression and apathy in patients with PD using multivariate analyses and an appropriate battery of tests of numerous factors, such as symptom severity and age, that might be related to QoL in PD.
Methods: A cross-sectional multicenter study was performed in 14 Japanese centers. Patients with PD (n = 314) and mini-mental state examination scores of 23 or more were recruited. The patients with PD completed the 36-item Short-Form Health Survey (SF-36), Beck Depression Inventory-2nd edition (BDI), and Apathy Scale. The scores were used to measure their QoL and symptoms of depression and apathy. A multiple regression analysis is performed to test the influence of 16 factors, including depression and apathy, on each domain of the SF-36, and the differences in the effects of depression and apathy on QoL are assessed.
Results: The BDI and Apathy Scale scores were significant independent variables in most SF-36 domains. However, their tendencies differed. BDI scores were significantly related to most SF-36 domains, especially the mental component. In contrast, Apathy Scale scores tended to be related to the physical component.
Conclusions: These results suggested that depression and apathy were significantly and independently associated with different QoL domains in patients with PD. These findings suggest that different strategies should be used to treat patients in these states.
To cite this abstract in AMA style:
H. Nagayama. Quality of Life in Parkinson’s Disease: Impact of Depression and Apathy [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/quality-of-life-in-parkinsons-disease-impact-of-depression-and-apathy/. Accessed May 15, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/quality-of-life-in-parkinsons-disease-impact-of-depression-and-apathy/