Session Information
Date: Wednesday, June 7, 2017
Session Title: Parkinson's Disease: Cognition
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: To investigate putative risk factors for the development of dementia in patients with Parkinson’s disease.
Background: Dementia in idiopathic Parkinson’s disease (PD) is a common during the course of the disease and deeply influences patients’ prognosis and quality of life and also has important consequences for caregivers.
Methods: A cross-sectional, descriptive, comparative study between demented and non-demented PD patients was conducted. One hundred thirty-one clinically diagnosed cases were enrolled. MRI of brain was done for all cases and structural CNS disease including secondary Parkinsonism were excluded. Active, uncontrolled seizure; any disability or unstable disease that might prevent the patient from completing study procedure, aphasia affecting participation, refused to participate, other psychiatric disorders non-related to PD, abusive use of alcohol or illicit drugs were excluded. Diagnosis of dementia was done by Neurologist based on DSM-IV and was assessed by Mini-Mental state examination (MMSE) score and Parkinson’s disease with dementia – Short Screen (PDD-SS) score. Depression was assessed using DSM-IV. Severity of disease was evaluated by the Hoehn and Yahr stage (H-Y I to V). Pre-designed questionnaire was used to collect socio-demographic and other clinical information. Data was analyzed through SPSS v 23(P<0.05 for statistical significance). All significant variables found in uni-variate analysis were analyzed into multivariate logistic regression model.
Results: The overall prevalence of dementia was 38.2%. The Mean (SD) age of the demented and non-demented patients was 73.32(8.86) and 63.98(6.19) years respectively. Male predominated in both the groups (52% vs.67.9%). In multivariate logistic regression model, age ≥ 70 years [OR=4.25, 95% CI (1.51- 7.86), p=0.031], Diabetes [OR=5.37, 95% CI (2.29-10.09); p=0.019], Hypertension [OR=7.63, 95% CI (2.69-13.01); p=0.011 ], Disease duration ≥ 5 years [OR=10.01, 95% CI (4.81-21.65); p<0.001 ], H-Y stage ≥ 3 [OR= 9.52, 95% CI (4.37-19.06); p<0.001] and Depression [OR=8.79, 95%CI (3.95-18.98);p<0.001] were significantly associated with dementia in PD.
Conclusions: The strongest risk associated for development of dementia in our case series were advancing age, having diabetes and hypertension, longer disease duration, higher disease stage and presence of depression.
To cite this abstract in AMA style:
M.I. Khalil, M.R. Rahman, S. Munira. Risk Factors for Dementia in Parkinson’s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/risk-factors-for-dementia-in-parkinsons-disease/. Accessed November 6, 2024.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/risk-factors-for-dementia-in-parkinsons-disease/