Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: We evaluated the role of subcortical structures in ongoing dementia in Parkinson’s disease (PD).
Background: Cortical neural correlates of ongoing cognitive decline in PD are suggested, however, the significance of subcortical structures in the development of dementia in PD has not been fully studied.
Methods: One hundred eighty-two patients with PD-mild cognitive impairment (PD-MCI) were classified as PD-MCI converters (n = 74) or PD-MCI non-converters (n = 108) based on whether they were subsequently diagnosed with dementia. We explored automatic analysis of subcortical brain structures using a computerized segmentation procedure.
Results: PD-MCI converters had a smaller local shape volume than PD MCI non-converters in bilateral putamen, bilateral thalamus, right caudate and right hippocampus. The thalamic local shape volume was closely associated with cognitive performance of semantic fluency and attention in patients with PD-MCI converters.
Conclusions: Subcortical local shape volumes in the basal ganglia and thalamus may serve as an important predictor for the development of dementia in PD.
To cite this abstract in AMA style:
S.J. Chung, J.-H. Shin, K.h. Cho, Y. Lee, H.S. Yoo, S.J. Chung, Y.H. Sohn, J.-K. Seong, P.H. Lee. Subcortical local shape volume analysis of progressive mild cognitive impairment in Parkinson`s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/subcortical-local-shape-volume-analysis-of-progressive-mild-cognitive-impairment-in-parkinsons-disease/. Accessed June 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/subcortical-local-shape-volume-analysis-of-progressive-mild-cognitive-impairment-in-parkinsons-disease/