Category: Parkinson's Disease: Non-Motor Symptoms
Objective: To determine the relationship between non-motor symptom (NMS) burden and quality of life in persons living with Parkinson’s disease (PD) recruited into the registry.
Background: PD is a complex neurodegenerative disorder characterized by motor and non-motor features. The NMS are known to have a negative impact on quality of life (QoL) in PD and the timely identification and management of NMS is one of the unmet needs in comprehensive PD care globally.
Method: The Nigeria PD Research registry is an ongoing nationwide clinical study recruiting persons with PD (defined by the United Kingdom PD Society Brain Bank criteria). The demographic, clinical and PD-specific motor and non-motor parameters are documented at baseline. Here we present baseline demographics, the NMS burden using the NMS scale (NMSS) and QoL using the PDQ-8.
Results: Data from1835 participants with PD were analysed for this report, comprised of 1333 (72.6%) males and 502 (27.4%) females with a mean cohort age of 63.9 ± 10.2 years. The female PD were older (64.6 ± 9.7 years) than the male PD (63.6 ± 10.3) years; p = 0.04. The mean NMS score for all PD was 34.9 ± 33.2, median of 25.0 (35). The NMS score did not differ between males [35.6 ± 33.1; median is 26.0(36)] and females [33.3 ± 33.6, median 23.0 (32)], p = 0.20. The mean PDQ-8 score overall was 23.2 ± 17.6 [median of 21.9 (25)]. The QoL was significantly worse in female PD with a PDQ-8 score of 24.6 ± 18.0; median 21.9 (21.8) versus 22.6 ± 17.4; median of 18.8 in males (25) (p =0.03). Overall, there was a positive correlation between the PDQ-8 score and total NMS score (r = 0.519; p = 0.000).
Conclusion: We report a worse QoL in female PD in the NPDR registry and a correlation between the NMS burden and QoL in our cohort. This underscores the importance of proactive identification and timely treatment of NMS in persons with PD and an intentional focus on female Nigerians with PD.
To cite this abstract in AMA style:
O. Odeniyi, O. Ojo, O. Agabi, N. Okubadejo, NPD. Research Network. The Association between Non-Motor Symptom Burden and Quality of Life in the Nigeria Parkinson Disease Research Network Registry [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/the-association-between-non-motor-symptom-burden-and-quality-of-life-in-the-nigeria-parkinson-disease-research-network-registry/. Accessed June 14, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-association-between-non-motor-symptom-burden-and-quality-of-life-in-the-nigeria-parkinson-disease-research-network-registry/