Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To examine whether there are differences of the change of finger surface temperature (FST) after short time cold stress test between Parkinson disease (PD), Multiple system atrophy (MSA) and control.
Background: PD and MSA patients shows autonomic failure including constipation and orthostatic hypotension even in the early phase, but the degree and the pattern of autonomic failure are different between these two diseases in the clinical and pathological view. Quite a number of PD patients show cold hand and foot which are suggested as autonomic dysfunction and some PD patients show chilblains in winter. On the other hand, there are some reports about MSA patients showing “cold hand sign”. However, the precise mechanism and the difference of cold hand between PD and MSA are not clear.
Methods: Clinically diagnosed nineteen PD and five MSA patients and seven patients’ families as controls were enrolled in this research. The patients taking medicines and having complications which may influence the autonomic symptoms are excluded. After resting more than 15 minutes in the room keeping temperature with 25°C and moisture with 50％, the patients soaked their one hand in the 4°C cold water for 10 seconds and were measured FST for 15 minutes by a thermography (FLIR E5). FST was measured at just proximal portion of middle finger nail by dedicated software (FLIR tools). We also examined the relation between the change of FST and clinical parameters including age, duration, severity, autonomic symptoms, smell, REM sleep behavior disorder and cardiac MIBG scintigraphy.
Results: PD group patients showed significantly slower recovery of FST than MSA group and MSA group patients showed significantly faster recovery of FST than PD group. (Improvement rate (3 minutes) PD: cont: MSA=0.121: 0.175: 0.223, p=0.028. (15 minutes) 0.242: 0.302: 0.317, p=0.041)。There were no clinical parameters significantly related to the change of FST.
Conclusions: There was significant difference of the change of FST between three groups. Short time cold stress test may differentiate between PD and MSA.
To cite this abstract in AMA style:M. Takahashi, A. Hagiwara, K. Abe, A. Inaba, S. Orimo. The difference of the change of finger surface temperature after short time cold stress test between Parkinson disease and Multiple system atrophy [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/the-difference-of-the-change-of-finger-surface-temperature-after-short-time-cold-stress-test-between-parkinson-disease-and-multiple-system-atrophy/. Accessed November 29, 2023.
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