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The progression rate of sporadic adult-onset cerebellar ataxia : 1-year follow up study

PW. Ko, HW. Lee, K. Kang (Daegu, Republic of Korea)

Meeting: 2019 International Congress

Abstract Number: 261

Keywords: Ataxia: Clinical features, Scales, Timed Up and Go test

Session Information

Date: Monday, September 23, 2019

Session Title: Ataxia

Session Time: 1:45pm-3:15pm

Location: Les Muses, Level 3

Objective: To assess progression rate of the sporadic adult-onset ataxia (SAOA) and usefulness of well-known evaluation tools.

Background: The sporadic adult-onset ataxia (SAOA) is a diagnosis which has degenerative and progressive ataxic symptoms, a specific acquired or genetic cause cannot be found. The cause and progress of the disease are not well known due to the complexity and difficulty of diagnosis. Therefore, we tried to measure the progress of gait and balance of patients with SAOA by evaluating the usefulness of  well-known assessment tools.

Method: SAOA subjects were selected in consecutive order from a prospectively enrolled ataxia registry. 20 adult patients with SAOA were enrolled. Patients were assessed at their first visit by a scaled for assessment and rating of ataxia (SARA), a timed up and go (TUG), and a 10-meter walking test and they were assessed again by same tools after 1 year.

Results: The initial total SARA value was 14.8 ± 3.7 (mean ± SD) and the total SARA value after 1 year was 15.6 ± 6.0 (mean ± SD) (p-value = 0.54). TUG values were found to be 17.6 ± 7.0 sec, 24.5 ± 9.0 steps at first, 20.5 ± 14.8 sec and 27.7 ± 9.7 steps after 1 year (p-value = 0.377, 0.067, respectively). The 10-meter walking test was deteriorated from 13.9 ± 4.8 seconds, 25.0 ± 7.1 steps to 20.3 ± 13.4 seconds 30.5 ± 9.4 steps after 1 year (p-value = 0.036, 0.002, respectively). There was no statistically significant difference in the SARA total value. However, there were statistically significant differences in walking, nose-finger test, and Heel-sheen slides subscales of SARA.

Conclusion: Since SAOA is a disease characterized by progressive ataxia, deterioration of walking and motor function has been observed in most patients. Especially the change of walking was the most prominent, and it was able to confirm a significant change in 10 m walking test and detailed items of SARA scale. By observing changes over a longer period of time and evaluating the natural progression rate of the disease, it is expected that it will be used as a tool to clarify the understanding of the disease and to measure the therapeutic effect of interventional management in the future.

To cite this abstract in AMA style:

PW. Ko, HW. Lee, K. Kang. The progression rate of sporadic adult-onset cerebellar ataxia : 1-year follow up study [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/the-progression-rate-of-sporadic-adult-onset-cerebellar-ataxia-1-year-follow-up-study/. Accessed June 13, 2025.
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