Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To identify sonographic biomarkers of PD (Parkinson´s disease).
Background: Study of Parkinson’s disease biomarkers could lead us to identify the disease at its earlier stages.
Methods: We used data from the Barcelona-AsIA study, a population-based prospective study. A random sample of 933 subjects older than 50 years without history of symptomatic vascular disease were included between 2007-2009. Transcranial sonography (TCS) was performed at baseline, assessing substantia nigra (SN) and raphe nuclei echogenicity, size of third ventricle and frontal horns of lateral ventricles. SN hyperechogenicity (hyperSN) was considered when area was ≥0.20cm2. Follow-up visits were scheduled between 2016-2017, with new TCS. Median time of follow-up was 7.16 years[6.91-7.75].
Results: 271 participants had available baseline and follow-up TCS. Mean age at baseline was 63.95+/-6.59years, 63.7% were males. At baseline, right SN echogenicity area was 0.12+/-0.068cm2, left 0.12+/-0.068cm2. Fourty-seven (14.69%) participants presented hyperSN. Third ventricle size was 0.41+/-0.155cm, right horn of the lateral ventricle 1.60+/-0.197cm, left 1.59+/-0.195cm. At follow-up visit, SN echogenicity was 0.128+/-0.007cm2 (right), 0.127+/-0.07cm2 (left). Fourty-eight (15%) participants presented hyperSN. Third ventricle size was 0.52+/-0.22cm, lateral ventricle right horn 1.66+/-0.27cm, left 1.68+/-0.27cm. Three of the 271 patients developed PD during follow-up. From those participants without hiperSN at baseline one developed PD (1/224;0.45%). The percentage of participants with hiperSN who developed PD was 4.25 % (2/47).
Conclusions: SN echogenicity did not change in this seven-years follow-up study. The size of the third and lateral ventricles seems to increase with time, possibly reflecting atrophy. Patients with hyperSN had higher probability of developing PD.
References: Berg D, Godau J, Walter U. Transcranial sonography in movement disorders. Lancet Neurol. 2008 Nov;7(11):1044-55.
To cite this abstract in AMA style:A. Crespo Cuevas, L. Ispierto, E. Lopez-Cancio, A. Planas, T. Canento, M. Hernandez-Pérez, R. Alvarez, D. Vilas. Ultrasonographic signatures associated with movement disorders (USA-MD study): A population-based longitudinal study [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/ultrasonographic-signatures-associated-with-movement-disorders-usa-md-study-a-population-based-longitudinal-study/. Accessed December 11, 2023.
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