MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Utilization and longitudinal impact of anticholinergic use in Parkinson’s disease. National Parkinson Foundation (NPF) QII registry

V. Felix Saunders, K. Li, S. Luo, T. Simuni (Chicago, IL, USA)

Meeting: 2016 International Congress

Abstract Number: 1959

Keywords: Parkinsonism

Session Information

Date: Thursday, June 23, 2016

Session Title: Parkinson's disease: Clinical trials, pharmacology and treatment

Session Time: 12:00pm-1:30pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To evaluate baseline predictors and longitudinal impact of anticholinergics use in Parkinson’s disease (PD).

Background: Anticholinergics have beneficial effect on tremor in PD but are known to have adverse impact on cognition in the elderly. Less clear, is the long-term impact of their use in PD.

Methods: Data were obtained from the NPF-QII database, an observational prospective longitudinal study, conducted at 21 NPF sites, with all PD patients eligible for enrollment. Data included demographics, comorbid conditions, PD stage/diagnosis, other treatments, and clinical conditions/outcomes. The baseline characteristics were compared for anticholinergic users versus nonusers. To assess long-term impact of anticholinergic use, newly prescribed users of anticholinergics were compared to nonusers using a generalized linear mixed model to regress each clinical outcome on the time-dependent “anticholinergic use” variable while adjusting for age, disease duration, Hoehn and Yahr (HY) stage, and initial score of outcome of interest.

Results: 7484 patients were included in the baseline dataset. Anticholinergic users were more likely to be younger, able to stand unaided, have a regular care partner, have an earlier age of PD diagnosis/symptoms, have a higher HY stage, have no motor fluctuations, not be on some form of levodopa, have better cognition level, and have fewer comorbid conditions. 4334 patients who had more than one visit were included in the longitudinal analysis. The mean follow up was 2.39 (SD 1.09) years. 160 were newly prescribed anticholinergics. Anticholinergic users had a lower scores on the cognitive recall test (-0.613%, t = -2.19, P= 0.0286), but no change in the total PDQ-39 or PDQ-39 cognition subscore.

Conclusions: As expected, patients prescribed anticholinergics tend to be younger, have an earlier PD diagnosis and be overall healthier. However, even in that selected subset of PD patients, long term use of anticholinergics is associated with a decrease in cognitive performance. Physicians should be vigilant of the long term negative cognitive effects of anticholinergics in PD although more data are necessary to assess whether the effect is permanent or reversible.

To cite this abstract in AMA style:

V. Felix Saunders, K. Li, S. Luo, T. Simuni. Utilization and longitudinal impact of anticholinergic use in Parkinson’s disease. National Parkinson Foundation (NPF) QII registry [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/utilization-and-longitudinal-impact-of-anticholinergic-use-in-parkinsons-disease-national-parkinson-foundation-npf-qii-registry/. Accessed September 21, 2023.
  • Tweet
  • Email
  • Print

« Back to 2016 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/utilization-and-longitudinal-impact-of-anticholinergic-use-in-parkinsons-disease-national-parkinson-foundation-npf-qii-registry/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Patients with Essential Tremor Live Longer than their Relatives
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Carpal Tunnel Syndrome in Patients with Tremor
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • #23972 (not found)
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Patients with Essential Tremor Live Longer than their Relatives
  • #22892 (not found)
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Effect of marijuana on Essential Tremor: A case report
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Insulin dependent diabetes and hand tremor
  • Patients with Essential Tremor Live Longer than their Relatives
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2023 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley