MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2016 International Congress

    Urate and homocysteine: Changes in motor and cognitive symptoms in newly diagnosed Parkinson’s disease

    I.J. Sleeman, R. Lawson, A. Yarnall, G. Duncan, F. Johnston, T. Khoo, D. Collerton, J.P. Taylor, D. Burn (Newcastle upon Tyne, United Kingdom)

    Objective: 1) To determine serum urate and homocysteine concentration at baseline, 18 and 36 months in control and PD participants. 2) To determine if urate…
  • 2016 International Congress

    Cell-surface expression of dopamine transporter facilitates the uptake of α-synuclein

    J. Kobayashi, T. Hasegawa, S. Yoshida, N. Sugeno, R. Oshima, A. Kikuchi, A. Takeda, M. Aoki (Sendai, Japan)

    Objective: We determined whether increased expression of DAT have an impact on the uptake of α-synuclein (αS). Background: The endocytosis of dopamine transporter (DAT) controls…
  • 2016 International Congress

    Role of dopamine and GABA during subthalamic and pallidal deep brain stimulation: Evidence of dopamine release during subthalamic Deep Brain Stimulation

    A. Nakajima, Y. Shimo, T. Uka, N. Hattori (Tokyo, Japan)

    Objective: We recorded the single-unit activity of striatal cholinergic interneurons of healthy monkeys during high-frequency stimulation (HFS) of the subthalamic nucleus (STN) and globus pallidus…
  • 2016 International Congress

    Associations between cerebrospinal fluid proteins and cytokines in Parkinson’s disease

    R. Wijeyekoon, S. Moore, K. Farrell, D. Breen, R. Barker, C.H. Williams-Gray (Cambridge, United Kingdom)

    Objective: To investigate the relationship between cerebrospinal fluid (CSF) proteins and cytokines, and their correlation with clinical measures in PD. Background: Several studies have investigated…
  • 2016 International Congress

    The small GTP-binding protein Rhes influences midbrain dopaminergic neurons: Behavioral and biochemical studies

    A. Pinna, F. Napolitano, G. Costa, P.F. Porceddu, L. Contu, J. Wardas, M.A. Casu, A. Usiello, M. Morelli (Cagliari, Italy)

    Objective: Rhes is a small GTP-binding protein highly enriched in the striatum, developmentally regulated by thyroid hormone, and by dopamine (DA) innervation in adult rat…
  • 2016 International Congress

    Parkinson’s disease onset on non-dominant side predicts greater motor disability

    T.A. Finseth, S. Sillau, B. Berman (Aurora, CO, USA)

    Objective: Evaluate (1) the effect of dominant-side onset (DSO) vs non-dominant-side onset (NDSO) of Parkinson's disease (PD) on motor impairment in a large multicenter cohort…
  • 2016 International Congress

    Mitochondrial Hsp90 inhibitor G-TTP triggers PINK1/parkin-dependent mitochondrial quality control

    F.C. Fiesel, J.D. Elle, H.R. Anneliese, H. Roman, S. Wolfdieter (Jacksonville, FL, USA)

    Objective: To characterize the response of cells treated with Gamitrinib-triphenylphosphonium (G-TTP) a mitochondrial targeted inhibitor of the chaperone Hsp90. Background: Upon dissipation of the mitochondrial…
  • 2016 International Congress

    ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

    T. Hasegawa, R. Oshima, K. Tamai, N. Sugeno, A. Kikuchi, J. Kobayashi, S. Yoshida, A. Takeda, N. Tanaka, M. Aoki (Sendai, Japan)

    Objective: Endosomal sorting required for transport (ESCRT) orchestrates endo-lysosomal soring of ubiquitinated proteins, multivesicular body formation. The aim of this study is to elucidate the…
  • 2016 International Congress

    Persistent drug-induced parkinsonism with normal dopamine transporter imaging

    J.W. Lee, J.Y. Hong, J.S. Oh, I. Lee, J.S. Kim, Y.H. Sohn, P.H. Lee (Wonju, Korea)

    Objective: We investigated whether patients with persistent drug-induced parkinsonism (DIP) showing visually normal dopamine transporter (DAT) imaging had minimal changes in striatal DAT activity using…
  • 2016 International Congress

    Topiramate responsive adult-onset opsoclonus myoclonus ataxia syndrome

    Y. Degirmenci, H. Kececi (Duzce, Turkey)

    Objective: Opsoclonus myoclonus ataxia (OMA) is a rare neurological syndrome characterized with with autoimmune background. However the exact pathophysiology is not clear. Most common underlying…
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