Premotor phase of PD in two GBA mutation carriers
Objective: To identify premotor phase of Parkinson's disease (PD) in obligate GBA heterozygous carriers. Background: GBA mutation carriers are in greater risk of developing PD.…A heterozygous splicing variant in NPC2 in a patient with PSP
Objective: Clinical, neuroimaging, genetic and biochemical characterization of a patient with a PSP-like phenotype carrying a splicing mutation in NPC2. Background: Niemann-Pick type C disease…Integrity of the superior longitudinal fascicle and its relationship with anticipatory postural adjustments in people with Parkinson’s disease and freezing of gait
Objective: To assess the integrity of the Superior Longitudinal Fascicle (SLF) and its relationship with the Anticipatory Postural Adjustments (APAs) of step initiation in people…Longitudinal measurements of cerebrospinal fluid biomarkers in Parkinson’s disease
Objective: To investigate whether cerebrospinal fluid (CSF) levels of tau, phosphorylated tau, β-amyloid42, α-synuclein, neurofilament light and YKL-40 change over time and if changes correlate…Differences between responders and non-responders of Istradefylline for the wearing off in Parkinson’s disease
Objective: Istradefylline is a selective antagonist of adenosine A2A receptor and was approved first in Japan for Parkinson's disease (PD) patients with by symptoms of…Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson’s disease subtype
Objective: To investigate whether Parkinson's disease (PD) motor subtypes differ in their levels of uric acid (UA), and if these differences correlate with the degree…Chronic cerebral hypoperfusion accelerates cognitive dysfunction and microvascular impairment in the MPTP mouse model of Parkinson’s disease
Objective: To evaluate cerebral hypoperfusion on cognitive dysfunction and related microvascular impairment in the MPTP mouse model. Background: Vascular pathology and Parkinson's disease (PD) pathology…Parkinson’s disease motor subtypes show similar deficits in inhibitory control
Objective: To determine whether predominant motor subtypes of Parkinson's disease (PD) differentially impact distinct forms of inhibitory motor control. Background: Parkinson's disease (PD) impairs rapid…α-synuclein CSF levels correlate with urinary dysfunction in early de novo Parkinson’s disease patients
Objective: To explore the association between levels of α-synuclein burden and urinary dysfunction in early de novo (untreated) Parkinson's disease (PD) patients. Background: Urinary dysfunction…Clinical predictors of airway protective dysfunction in Parkinson’s disease
Objective: The goal of this study was to test the sensitivity and specificity of several airway protective and disease-specific factors for predicting swallowing safety in…
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