The impact of levodopa and apomorphine on beta- and gamma-oscillations in cortico-basal ganglia circuits in experimental parkinsonism
Objective: To clarify the role of pathologic oscillations in Parkinson's disease (PD) we recorded local field potentials (LFPs) in cortico-basal ganglia circuits of Parkinsonian and…An exuberant cortical γb influences the unmasking and intensity of dyskinesia in 6-OHDA-treated freely-moving rats
Objective: To clarify the pathogenetic role of Beta band (βb) and Gamma band (γb) in 6-OHDA-treated freely-moving rats, by combining histochemical and electrophysiological investigations. Background:…Glucocerebrosidase activity in a cohort of PD patients
Objective: To evaluate glucocerebrosidase (GCase) activity in peripheral blood mononuclear cells (PBMCs) of a cohort of 53 PD patients with and without GBA mutations and…APL-130277 is a sublingual film being studied in phase 3 trials to rapidly turn patients ON from OFF episodes by delivering apomorphine via the oral mucosa
Objective: Evaluate if any differences exist in the efficacy of APL-130277 doses to turn a patient with Parkinson's disease (PD) from OFF to fully ON…Colonic microbiome in Korean patients with Parkinson’s disease
Objective: In this study we investigated the relationship between colonic microbiome and clinical features of the patients with homogeneous ethnicity. Background: Colonic microbiome is an…In idiopathic Parkinson’s disease: The effect of using L-dopa on peripheral nerves
Objective: Idiopathic Parkinson's disease (IPD) is a chronic neurodegenerative disorder. Most of the clinicians believe that it is limited with motor and cognitive disorders. However,…1 to 40 years later: Delayed effects of brain radiation presenting as parkinsonism
Objective: To report 3 adult cases of delayed radiation induced parkinsonism, with latency ranging from 1 to 40 years. . Background: Unequivocal radiation induced parkinsonism…The phenotypic and genetic features of myoclonus-dystonia in six Saudi Arabian kindreds
Objective: To study the motor symptoms, psychiatric and neuropsychological features and genetic findings of patients with familial dystonia with or without myoclonus in a movement…The interrater variability in clinical assessment of post-hypoxic myoclonus
Objective: To investigate the interrater variability in clinical assessment of acute post-hypoxic myoclonus (PHM) after cardiopulmonary resuscitation. Background: PHM is a clinical symptom that can…A phase 3, placebo-controlled study with an open-label extension: Sustained incobotulinumtoxinA efficacy in upper-limb post-stroke spasticity over 48 weeks
Objective: To assess the efficacy and safety of incobotulinumtoxinA for upper-limb post-stroke spasticity. Background: Botulinum toxin injections are a recommended therapy for limb spasticity. We…
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