Effect of genetic variation in SNCA and APOE on cerebrospinal fluid protein levels in patients with Parkinson’s disease and controls
Objective: To determine whether genetic variability constitutes a source of heterogeneity in levels of cerebrospinal fluid (CSF) proteins in patients with Parkinson's disease (PD) and…Risk prediction modeling in Parkinson’s disease using genetic and environmental/lifestyle factors
Objective: To assess the potential of Parkinson's disease (PD) risk prediction using a comprehensive list of genetic and environmental/lifestyle factors associated with PD. Background: Parkinson's…Deficiency of HGprt in Lesch-Nyhan disease is associated with abnormal dopaminergic neurodevelopment in vivo
Objective: To determine the in vivo effects of hypoxanthine-guanine phosphoribosyl transferase (HGprt) deficiency on dopaminergic neurodevelopment in a genetic mouse model of Lesch-Nyhan disease (LND).…Differentiated versus undifferentiated mesenchymal stem cell therapy in paraquat model of Parkinson’s disease
Objective: To investigate the effect of undifferentiated versus differentiated CD34 stem cells series on paraquat model of PD and to elucidate the mechanism of action…Toward a new biomarker on Parkinson’s disease: Study of alpha synuclein on upper enteric system by endoscopy
Objective: The aim of our study was to investigate the alpha synuclein deposition at the enteric nerve system on patient with Parkinson's disease and provide…Clinical aspects of postural instability in Parkinson’s disease
Objective: To identify the clinical features of postural instability by PD patients. Background: Postural instability (PI) to maintain body balance while walking. The causes of…Hyperin inhibits lipopolysaccharide-induced microglia activation through p38 and NFκB signaling
Objective: In this study, we aimed to investigate hyperin's potentiality in inhibition of neuroinflammation. Background: Hyperin is an active compound isolated from Rhododendron brachycarpum G.…Long-duration response to levodopa in Parkinson’s disease is independent of disease duration: A prospective study on de novo patients in Ghana
Objective: To prospectively investigate the response to acute levodopa challenge in patients with advanced Parkinson's disease (PD) never treated before. Background: Pathophysiological mechanisms underlying motor…Lewy body extracts from Parkinson’s disease brains as models for high-throughput screens of neurotoxicity and α-synuclein spreading from cell-to-cell
Objective: To validate the effect of Lewy body extracts from Parkinson's disease (PD) brains in high-throughput screens of neurotoxicity and the α-synuclein (α-syn) spreading from…Evaluation of regional changes in striatal DAT binding in a progressing Parkinson’s disease (PD) cohort: Lessons for imaging biomarker assessment in disease-modifying therapeutic trials
Objective: To evaluate subregion-dependent striatal changes in dopamine transporter (DAT) binding using 123-I Ioflupane SPECT in PD participants in the Parkinson Progression Marker Initiative (PPMI)…
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