Can intraoperative clinical testing really predict the effects of deep brain stimulation in the subthalamic nucleus?
Objective: To evaluate whether stimulation-induced therapeutic and side effects of the permanent electrode are predictable by intraoperative test stimulation with clinical examination. Background: Intraoperative test…Multiple-source current steering in bilateral subthalamic nucleus deep brain stimulation for Parkinson’s disease: Our experience
Objective: To evaluate the efficacy and side effects of a multiple-source, constant-current device in a Latin-American population of patients with PD. Background: Timmermann et al.…Clinical characteristics of Parkinson’s disease and essential tremor patients undergoing deep brain stimulation surgery: Five-year data from Columbia University Medical Center (2009 – 2014)
Objective: To compare the clinical characteristics of essential tremor (ET) and Parkinson's disease (PD) patients who underwent deep brain stimulation (DBS) surgery to those of…Identification of unique metabolite signatures in post-mortem DBS human tissue using LC-HRMS
Objective: Metabolomics is applied to the study of metabolic as well as neurodegenerative diseases. We propose to utilize this technique to detect metabolic changes from…Neurophysiological assessment of corticospinal tract activation due to subthalamic deep brain stimulation in patients with Parkinson’s disease
Objective: To assess current spread to the corticospinal tract (CST) in patients with Parkinson's disease (PD) treated with bilateral Deep Brain Stimulation (DBS) of the…Speech 10 years post bilateral STN-DBS for Parkinson’s disease
Objective: This study reports on the type and severity of speech problems up to 10 years after bilateral deep brain stimulation (DBS) of the subthalamic…Neuropsychological safety of bilateral pallidal (GPi) deep brain stimulation (DBS) for Parkinson’s disease (PD) under general anesthesia
Objective: To evaluate neuropsychological outcome of bilateral GPi DBS carried out under general anesthesia using a combination of direct anatomical targeting and intraoperative computed tomography…Clinical outcome of constant current deep brain stimulation in patients with medication-refractory essential tremor
Objective: To evaluate, for the first time, the safety and efficacy of long-term ventralis intermedius (Vim) constant current deep brain stimulation (DBS) in essential tremor…Results from a double-blind trial of pallidal DBS for Tourette’s syndrome: Are there any predictors of surgery outcome?
Objective: To explore whether individual patient characteristics can indicate response to treatment in a trial of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS)…Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy
Objective: To assess the therapeutic efficacy of the caspase-1 inhibitor prodrug VX-765 on alpha-synuclein (α-syn) pathology and neuroprotection in a transgenic mouse model of multiple…
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