Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate the incidence of adverse events and postoperative infections of IPG replacements in a multicenter cohort.
Background: Deep brain stimulation (DBS) is a growing treatment modality and most DBS systems require replacement of the implantable pulse generator (IPG) every few years. The literature is rather scarce regarding the potential impact of the adverse events of IPG replacements on the longevity of DBS treatments.
Methods: Medical records of 808 patients from one Australian and five Swedish DBS centers with a total of 1293 IPG replacements were audited. A logistic regression model was used to ascertain the influence of possible predictors on the incidence of adverse events.
Results: The overall incidence of major infections was 2.3% per procedure, 3.7% per patient and 1.7% per replaced IPG. 93.3% of these patients needed partial or complete removal. DBS removal became permanent in 7 cases. There were statistical significant increased risk of infection for males (OR 3.6, p= 0.026) and for each previous IPG replacement (OR 1.6, p< 0.005).
Conclusions: The risk of postoperative infections of IPG replacements in DBS increase with each previous procedure and there is need to develop strategies to reduce the frequency of IPG replacements.
To cite this abstract in AMA style:E. Jiltsova, A. Fytagoridis, T. Heard, J. Samuelsson, P. Zsigmond, S. Skyrman, T. Skoglund, T. Coyne, P. Silburn, P. Blomstedt. Surgical replacement of implantable pulse generators in deep brain stimulation: Adverse events and risk factors in a multicenter cohort [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/surgical-replacement-of-implantable-pulse-generators-in-deep-brain-stimulation-adverse-events-and-risk-factors-in-a-multicenter-cohort/. Accessed December 7, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/surgical-replacement-of-implantable-pulse-generators-in-deep-brain-stimulation-adverse-events-and-risk-factors-in-a-multicenter-cohort/