Investigating the role of Parkin in mitigating oxidative stress
Objective: We are investigating the ability of Parkin protein to protect cells from oxidative stress (OS) and the mechanisms that underlie this function. We hypothesize…Minimum MDS-UPDRS part III change needed to convert a Parkinson’s disease patient from the OFF to full ON state with apomorphine sublingual film (APL-130277)
Objective: Determine the minimum MDS-UPDRS Part III improvement needed to convert a patient from the morning OFF state to a full ON with APL-130277. Background:…Alterations in 14-3-3 protein phosphorylation as a biomarker for neurodegeneration
Objective: To examine whether 14-3-3 phosphorylation is altered in Parkinson's disease and other neurodegenerative disorders. Background: 14-3-3 proteins are a highly conserved family of proteins…Pathophysiological mechanisms of bone mass loss for osteoporosis prevalence in Parkinson’s disease
Objective: Quantify the impact of osteoporosis in Parkinson's disease to know factors that caused bone loss. Background: Parkinson´s disease (PD) and osteoporosis are two conditions…Chorea – Ballism drug induced in replacement treatment with thyroid hormones – Case presentation
Objective: We present the case of a 56 years-old female patient that presented chorea movements after the initiation of replacement treatment with thyroid hormones. Background:…Post-anoxic myoclonus: Timing matters
Objective: To highlight that timing of post-anoxic myoclonus following initial anoxic injury can result in markedly different outcomes. Background: Post-anoxic myoclonus is typically considered a…Turkish version of the Johns Hopkins restless legs syndrome quality of life questionnaire (RLS-QoL): Validity and reliability study
Objective: Our aim was to modify the Restless Legs Syndrome Quality of Life (RLS-QoL) questionnaire advanced by Abetz (Health Qual Life Outcomes 3:79, 2005) and…Muscle selection patterns for injection of onabotulinumtoxinA in adult patients with post-stroke lower-limb spasticity influence outcome: Results from a double-blind, placebo-controlled phase 3 clinical trial
Objective: The objective of this analysis is to identify an optimal muscle selection pattern for onabotulinumtoxinA injection for the treatment of post-stroke lower-limb spasticity (PSLLS).…Frontal dysfunction in Tourette syndrome: A PET-FDG study
Objective: Our objective was study the metabolism of brain in a group of patients with Tourette´s Syndrome. Background: The pathophysiology and anatomical basis of Tourette…Is tremor related to celiac disease?
Objective: To evaluate the prevalence and clinical correlates of tremor in CD. Background: Celiac disease (CD) is a systemic autoimmune disease, whose prevalence is of…
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