Hydrogen sulfide functions as a neuromodulator to regulate striatal neurotransmission in a mouse model of Parkinson’s disease
Objective: To Evaluate:prepared a MPTP/p induced mouse subacute model of PD, and explore the modulatory effect of H2S on monoamine and amino acid neurotransmitters in…Inhibition of cathepsin D enhances the autophagy lysosome pathway dysfunction and α-synuclein aggregation in experimental parkinsonism
Objective: To explore the mechanism of CTSD inhibition in the dysfunction of autophagy-lysosome pathway and aggregation of α-synuclein in Parkinson's disease. Background: α-synuclein, the main…Effect of repeated intravenous amantadine infusions in patients with Parkinson’s disease
Objective: To examine the long-term effect of repeated boosts of intravenous amantadine in patients with PD with and without response fluctuations and dyskinesias. Background: Amantadine…Computational assessment of calcium channel effects on subthalamic nucleus neuronal cells: Study of abnormal bursting patterns in Parkinson’s disease
Objective: Understanding the drug effects with respect to various ion channels on subthalamic nucleus (STN) cells is the key to safety pharmacology assessment. Here our…A double blind investigation of efficacy and safety of incobotulinumtoxinA in Parkinson’s disease tremor- A customized injection approach
Objective: To evaluate the safety and efficacy of incobotulinumtoxinA (IncoA) injection in the tremor of Parkinson's disease (PD). Background: Unlike other cardinal motor features of…Serum level of vitamin D3 in patients with neurodegenerative diseases compared to healthy adults and its correlation with the years spent from the initial diagnosis
Objective: Vitamin D is an important factor responsible for many physiologic functions. Vitamin D deficiency is associated with increased risk of neurodegenerative disease. Background: The…Group climate in the voice therapy of patients with Parkinson’s disease
Objective: To examine the impact of coaching and group dynamics activities in the voice, speech and communication of Parkinson's disease (PD) patients, as well as…Activities of daily living and motor scores of the UPDRS in fluctuating Parkinson’s disease patients treated with opicapone
Objective: Evaluate the effects of opicapone (OPC) on the activities of daily living and motor scores of the UPDRS in fluctuating Parkinson's disease patients. Background:…Association of Parkinson’s disease with essential tremor
Objective: In this study we present the clinical characteristics of 10 patients (6 males, 4 females) with both essential tremor (ET) and Parkinson's disease (PD).…Clinical and biological predictors of time to initiation of symptomatic therapy in early Parkinson’s disease
Objective: To determine clinical and biological variables that predict time to initiation of symptomatic therapy (TIST) in de novo Parkinson's disease (PD) patients. Background: There…
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