Brain metabolic profile changes reflect subtle pathological alterations in different murine models of Parkinson’s disease
Objective: Understanding early, and therefore often subtle, disease processes in Parkinson's disease (PD) is essential for the development of disease modifying cures. But in patients,…Enteric neurons reveal substantial in vivo mitochondrial changes in Parkinson’s disease
Objective: Study in vivo mitochondrial and ganglionic morphometrics of enteric neurons in Parkinson's disease. Background: While well established in autopsy studies, the crucial role of…Characterization of striatal TH-immunoreactive cells in chronic and acute L-DOPA treatment in a mice model of Parkinson´s disease
Objective: To characterize Tyrosine Hydroxylase immunoreactive cells (TH-ir) in a mouse model of hemiparkinsonism and L-DOPA induced dyskinesia. Background: L-DOPA-induced dyskinesias (LID) are a severe…Striatal PDE10 expression in Parkinson’s disease (PD) and healthy controls using [18F]MNI-659 PET imaging
Objective: To evaluate the feasibility of [18F]MNI-659 PET, a striatal PDE10A imaging tracer, as a imaging biomarker in PD. Background: PDE10 is highly and specifically…Longitudinal cerebrospinal fluid biomarkers in early Parkinson’s disease and healthy controls
Objective: To analyze changes in levels of four distinct biomarkers in drug-naïve Parkinson's disease (PD) subjects in cerebrospinal fluid (CSF) over 6- and 12 mo…Valproate-associated parkinsonism – A critical review of the literature
Objective: To provide a critical review of the existing literature on valproate-associated parkinsonism and to discuss possible mechanisms. Background: Valproate was first approved as an…Transient myoclonic state in the elderly: A new entity in the classification of myoclonus
Objective: To clarify the clinical picture of transient myoclonic state in elderly patients and to establish a position in the classification of myoclonus. Background: Transient…Neurophysiological investigation of brainstem in idiopathic REM sleep behavior disorder (iRBD) through vestibular evoked myogenic potentials (VEMPs)
Objective: To investigate the degree of brainstem impairment in a cohort of patients with iRBD through recording of a VEMPs battery able to indirectly assess…The temporal relationship between premonitory sensations and tics compared to obsessions
Objective: Investigating the real-time relationship between premonitory urges and tics as compared to the urge to blink in healthy controls and the urge to execute…Individualized botulinum toxin type A therapy of bilateral upper limb essential tremor by multi-sensor kinematic technology
Objective: To demonstrate efficacious and safe reduction in bilateral upper limb tremor severity by serial botulinum toxin type A injection parameters kinematically determined using a…
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