Safety and efficacy of escalating doses of incobotulinumtoxinA (400-800U): Increasing improvements in disability due to multifocal upper- and lower-limb spasticity
Objective: To assess the safety and efficacy of escalating incobotulinumtoxinA doses (400-800U) in patients with spasticity. Background: Botulinum toxin treatment at higher doses than currently…Do different tic phenotypes have different responses to comprehensive behavioral intervention for tics (CBIT)?
Objective: To evaluate 1) the types of tics undergoing CBIT at an expert movement disorders center and 2) to evaluate the response of each tic…Altered connectivity within the cerebello-thalamo-cortical network in essential tremor: A resting state fMRI study
Objective: To evaluate the tremor network in Essential Tremor(ET) patients in rest conditions with respect to Healthy Controls(HC). Background: Pathophysiology of ET is poorly understood.…Isolated finger tremor in Parkinson’s disease and essential tremor
Objective: To establish whether isolated hand fingers tremor (IFT) is more frequent in Pakinson's (PD) disease than in essential tremor (ET). Background: Postural tremor may…Quantitative assessment of DBS-induced gait disorder in patients with essential tremor
Objective: To investigate changes in gait coordination quantitatively in patients with essential tremor (ET) under chronic bilateral high-frequency stimulation of the nucleus ventralis intermedius (VIM).…Sub-acute rapidly progressive cerebellar ataxia – A case of JC virus associated granule cell neuronopathy (GCN)
Objective: To describe a case of JC virus associated GCN. Background: JC virus associated CNS disease most commonly presents as progressive multifocal leukoencephalopathy. A less…Psychogenic movement disorder in cerebellar atrophy
Objective: Description of a patient with psychogenic movement disorder showing cerebellar atrophy in neuroimaging. Background: Psychogenic movement disorders are typically characterized by abnormal involuntary movements…Testing candidate transcriptional biomarkers of asymtpomatic and symptomatic stages in spinocerebellar ataxia type 3 (SCA3)
Objective: To investigate the potential of nine candidate genes as transcriptional biomarkers of asymptomatic and symptomatic stages of spinocerebellar ataxia type 3 (SCA3). Background: An…The nucleocytoplasmic transport of ataxin-3 as pathogenic mechanism in spinocerebellar ataxia type 3
Objective: Spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) is a neurodegenerative disorder caused by a CAG expansion in the MJD1 gene leading to…CAG repeat length and weight loss in pre-manifest Huntington’s disease
Objective: To explore if CAG repeat length is a predictor of weight loss in pre-manifest Huntington's disease. Background: Weight loss is a hallmark finding in…
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