Levodopa, placebo and rotigotine change biomarker levels for oxidative stress
Objective: The objective was to investigate the influence of the D1 receptor agonists levodopa and rotigotine compared with placebo on homocysteine and cysteinyl-glycine in plasma…Combined stimulation of STN and SNr for resistant freezing of gait in Parkinson’s disease (STN+SNr) – A multicenter randomized controlled trial
Objective: 54 patients with idiopathic Parkinson's disease and freezing of gait resistant to subthalamic nucleus stimulation and dopaminergic medication will be included into this German-wide…Strategies to improve drug development efficiency through regulatory interactions, minimizing the placebo effect and improving data integrity within a phase 3 study of tozadenant in Parkinson’s disease patients with motor fluctuations (TOZ-PD)
Objective: To identify and implement strategies to improve the efficiency of drug development in Phase 3 studies. Background: Conducting global clinical trials can be challenging,…A multi-site survey of Parkinson’s disease deep brain stimulation center best practice: moving toward a standard of care for DBS
Objective: To survey how Deep Brain Stimulation (DBS) Centers handle referrals and peri-operative (surgical and non-surgical) treatment of persons with Parkinson's disease (PD). Background: Currently…Comparing the characteristics of patients with Parkinson’s disease speech with and without deep brain stimulation
Objective: To compare the speech Parkinson's disease (PD) patients with and without deep brain stimulation. Background: Among the many changes, the presence of dysarthria, characterized…Measurement of effect of variable deep brain stimulation (DBS) frequencies on static postural control in Parkinson’s disease (PD) patients with bilateral STN or GPi stimulators by employing force plate
Objective: To quantitatively evaluate the effect of variable DBS frequencies on static postural control in Parkinson's disease (PD) patients with Bilateral STN or GPi stimulators…Evaluation of the accuracy of stereotactic DBS electrode implantation by post-operative image fusion
Objective: The precision in implantation of deep brain stimulation (DBS) electrodes based on pre-operative MRI planning is of utmost importance for the success of this…Wearable sensors and decision algorithms for advanced therapy referral in Parkinson’s disease
Objective: Pilot study to determine the impact of remote monitoring using objective, wearable sensors on the advanced therapy referral rate in patients with advanced Parkinson's…Assessment of freezing of gait in Parkinson’s disease patients treated with STN-DBS
Objective: To evaluate FOG in patients with PD treated with STN-DBS and to compare sensitivity of different assessments of FOG in this specific group of…Tourette syndrome treated by continuous electrical neuromodulation (DBS): Targeting the comorbidities?
Objective: To assess the response to deep brain stimulation (DBS) in refractory Tourette syndrome (rTS) of both tics and behavioural comorbidities. Background: Gilles de la…
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