Extended-release carbidopa-levodopa, IPX066: Dosing and efficacy with concomitant medication use in Parkinson’s disease
Objective: Evaluate the efficacy and dosing of IPX066 in patient groups taking concomitant Parkinson's disease (PD) medication, using post hoc subgroup analyses. Background: IPX066 is…Rasagiline treatment for sleep disorders in Parkinson’s disease (RaSPar) – Double-blinded, randomized, placebo-controlled, placebo run-in-phase, polysomnography clinical trial
Objective: To study the effects of Rasagiline on sleep disturbances measured by polysomnographic (PSG) evaluation of sleep efficacy and secondary measures as other sleep variables,…Efficacy of apomorphine subcutaneous injections in patients with levodopa dose failures and morning akinesia
Objective: To assess the effect of subcutaneous injection of apomorphine (APO) in patients with Parkinson's disease (PD)and morning akinesia who experience dose failures after their…A clinical trials ‘charter’ to improve communication about, recruitment to and retention in Parkinson’s clinical trials
Objective: The objective of the project was to design a durable tool, usable by clinical trial investigators and participants alike, that would improve subject retention…Global implementation of efficacious voice treatment for Parkinson’s disease: LSVT LOUD: Germany®
Objective: This project was designed to evaluate the implementation of an efficacious voice treatment (LSVT LOUD) developed in the USA and designed to improve speech…RE-024: A potential phosphopantothenate replacement therapy in 2 patients with pantothenate kinase-associated neurodegeneration (PKAN)
Objective: To evaluate the safety and potential efficacy of RE-024 in open treatment of 2 patients with PKAN. Background: PKAN is an autosomal recessive, neurodegenerative…Chronic directional subthalamic nucleus deep brain stimulation in Parkinson’s disease – A pilot study
Objective: This pilot study aimed to assess the therapeutic potential of chronically implanted directional DBS leads in patients with Parkinson's disease. Background: The therapeutic effect…Clinical characteristics of Parkinson’s disease and essential tremor patients undergoing deep brain stimulation surgery: Five-year data from Columbia University Medical Center (2009 – 2014)
Objective: To compare the clinical characteristics of essential tremor (ET) and Parkinson's disease (PD) patients who underwent deep brain stimulation (DBS) surgery to those of…Identification of unique metabolite signatures in post-mortem DBS human tissue using LC-HRMS
Objective: Metabolomics is applied to the study of metabolic as well as neurodegenerative diseases. We propose to utilize this technique to detect metabolic changes from…Neurophysiological assessment of corticospinal tract activation due to subthalamic deep brain stimulation in patients with Parkinson’s disease
Objective: To assess current spread to the corticospinal tract (CST) in patients with Parkinson's disease (PD) treated with bilateral Deep Brain Stimulation (DBS) of the…
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