Safety and tolerability of inhaled levodopa (CVT-301) administered to Parkinson’s disease patients with motor fluctuations
Objective: Two Phase 2 studies were conducted to evaluate the safety profile of inhaled CVT-301 administered to Parkinson's disease (PD) patients with motor fluctuations. Background:…Efficacy of 4845 botulinum toxin (BoNT) treatment cycles, and clinical strategies after a failed cycle
Objective: To explore 1) relationship between peak benefit and Duration of Adequate Response (DAR) after BoNT, 2) frequency & causes of secondary Treatment Failure (TF),…Copper chelation efficacy of alginate/chitosan based D-penicillamine nanoparticles in rat model of non-Wilsonian brain copper toxicosis
Objective: To evaluate the copper (Cu) chelation efficacy of orally administered D-penicillamine loaded nanoparticles to that of conventional D-penicillamine therapy for 90 days in Wistar…A double-blind randomized controlled trial of cognitive training for freezing of gait in Parkinson’s disease
Objective: To investigate the potential of cognitive training to improve symptoms of freezing of gait in Parkinson's disease. Background: Freezing of gait (FOG) is a…Lead angle matters: Side effects of deep brain stimulation improved with adjustment of lead angle
Objective: A variety of technical considerations influence the outcome of Deep Brain Stimulation (DBS). We highlight a case where revising the angle of approach significantly…Non-motor outcomes of subthalamic stimulation in Parkinson’s disease depend on the location of active contacts
Objective: To investigate the impact of active electrode contact location on non-motor outcomes in patients with Parkinson's disease (PD) and subthalamic nucleus (STN) deep brain…Tractography patterns of subthalamic nucleus deep brain stimulation
Objective: To assess the connectivity patterns that characterize clinically beneficial electrodes in Parkinson's disease patients, after deep brain stimulation of the subthalamic nucleus. Background: Deep…Improvement of impulse control disorder in Parkinson’s disease patients treated with subthalamic nucleus stimulation
Objective: To find effects of subthalamic deep brain stimulation on impulse control disorder in patients with Parkinson's disease. Background: Parkinson's disease (PD) is a common…An investigation of Parkinson’s disease patients’ desired control over the DBS stimulator
Objective: To understand changes in patients' desired control of the DBS stimulator in a consecutive series of subjects who underwent DBS for the treatment of…Accuracy of intraoperative CT during DBS procedures: Comparison with postoperative MRI
Objective: To determine the accuracy of intraoperative CT (iCT) in localizing deep brain stimulation (DBS) electrodes by comparing this modality with postoperative magnetic resonance imaging…
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