Automated dosing schemes for administration of microtablets of levodopa for Parkinson’s disease, using wearable sensors
Objective: The aim of this study is to investigate the feasibility of using a dose optimization algorithm for dose individualization of microtables of levodopa. Background:…Evaluation of rotigotine transdermal patch in combination with low or high dose levodopa in patients with Parkinson’s disease: post-hoc analysis
Objective: To investigate the value of adding the dopamine agonist (DA) rotigotine (RTG) to low (<400mg/day) or high (≥400mg/day) levodopa (Ldopa) doses in patients with…ND0701: A new concentrated formulation of Apomorphine for continuous subcutaneous administration – human PK data
Objective: To evaluate the PK and relative bioavailability of ND0701, a subcutaneously (SC) infused apomorphine-base product candidate, and a commercial apomorphine-HCl product. The secondary objective…Improvement in attention/memory domains in advanced Parkinson’s disease patients treated with levodopa-carbidopa intestinal gel is associated with better quality of life
Objective: To evaluate the relationship between non-motor symptom (NMS) severity, quality of life (QoL), and activities of daily living (ADL) in advanced Parkinson’s disease (PD)…The effect of early STN-DBS in PD patients on axial symptoms: a 2-year randomized controlled trial (EARLYSTIM-Gait analysis)
Objective: This study assesses the effect of STN-DBS in early PD patients on axial symptoms compared to BMT. Background: In well-selected candidates, STN-DBS offers symptom…Efficacy and Safety of Therapeutic Interventions to Treat Motor Symptoms in Late Stage Parkinson’s Disease: A Systematic Review
Objective: Evaluate the efficacy and safety of therapeutic interventions to treat the motor symptoms in late stage PD. Background: PD patients in late stage are…Understanding neural activation in semantic fluency in Parkinson’s disease with mild cognitive impairment
Objective: To identify neural mechanisms relating to semantic fluency deficits in PD-MCI and to establish possible neuroimaging markers for Parkinson’s disease (PD) with dementia. Background:…Morphometric changes in Parkinson’s disease manifesting freezing of gait
Objective: To study structural Gray Matter (GM) and White Matter (WM) changes in Parkinson’s Disease (PD) patients with Freezing of Gait (FOG). Background: FOG is…The combination of the MIBG myocardial scintigraphy and DATSPECT contributes to the diagnosis of PD and other related disorders.
Objective: To evaluate MIBG and DAT SPECT for the diagnosis of Parkinson’s disease (PD) and related disorders, we performed 123I-meta-iodobenzylguanzylguanidine (MIBG) myocardial scintigraphy and (123I)-FP-CIT…Brain structural and functional changes associated with frequent falls in Parkinson’s disease
Objective: We investigated brain structural and functional changes associated with falls. Background: Gait and balance disorders are one of the common clinical features of Parkinson’s…
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