Using cognitive computing to identify compounds with antidyskinetic potential for Parkinson’s disease
Objective: IBM Watson for Drug Discovery (WDD) is a platform that analyzes vast quantities of scientific data to help researchers identify hidden connections and formulate…Rotenone induces astrocyte-mediated non-cell autonomous dopaminergic neurotoxicity
Objective: In this study, we examined involvement of astrocytes in rotenone-induced dopaminergic neurotoxicity using primary cultured cells. Background: Several studies reported that pesticide exposure, such…Tau predicts cognitive impairment in a prospective longitudinal CSF study in Parkinson’s Disease
Objective: We hypothesize that CSF profiles of Aβ and Tau (total and phosphorylated) are associated with clinical subtypes and disease progression. Background: Parkinson’s disease (PD)…The Cats & Dogs Test: a web-based platform to detect early visual processing deficits in Parkinson’s disease
Objective: To develop a sensitive web-based test to detect visuo-perceptual deficits in patients with Parkinson’s disease as an early marker of dementia. Background: Up to…Variation in Longevity Gene KLOTHO Associates with Measures of Resilience Against Parkinson’s Disease
Objective: We investigated whether carrying one copy of the protective haplotype “KL-VS” of the longevity gene KLOTHO is associated with better cognitive functioning and/or attenuated…Event-related potentials and mild cognitive impairment in Parkinson’s disease.
Objective: To measure N170, P3a/P3b peak amplitudes and latencies in PD with (PD-MCI) and without (PD-NC) mild cognitive impairment and to correlate them with clinical-demographic, neuropsychological and…Neurodegenerative biomarker abnormality frequency in idiopathic REM sleep behavior disorder
Objective: To describe the frequencies of neurodegenerative biomarker abnormalities in the adult Mayo Clinic iRBD prospective registry cohort. Background: The majority of patients with idiopathic…Parkinson’s disease in untreated Gaucher patients is associated with reduced glucosylsphingosine (Lyso-Gb1) serum levels
Objective: To assess the role of glycosphingolipids in increased risk of Parkinson's disease (PD) in patients with Gaucher disease (GD). Background: Patients with GD are…The therapeutic effect of MANF in the MPTP/MPP+-induced model of Parkinson’s disease
Objective: To observe therapeutic effect of MANF in the attenuation of neurotoxin MPTP/MPP+-induced model of Parkinson's disease Background: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a…Parkinsonian Features in a Cohort of Gaucher’s Disease (GD) Patients and Relatives.
Objective: to investigate the prevalence and clinical features of parkinsonism in a cohort of 21 GD patients and their relatives. Background: GD is a lysosomal…
- 1
- 2
- 3
- …
- 155
- Next Page »