Clinical utility of chronic directional subthalamic Deep Brain Stimulatoin in Parkinson’s Disease
Objective: Here, we present our 3-month clinical experience with subthalamic directional DBS in treating Parkinson’s disease (PD) symptoms. Background: Directional Deep Brain Stimulation (DBS) is…Twiddler Syndrome in Deep Brain Stimulation
Objective: Twiddler syndrome is one of the major complications in DBS treatment. Background: The patient intentionally and subconsciously spins internal pulse generator Spinning generally causes…Effect of Deutetrabenazine on Quality of Life in Patients With Tardive Dyskinesia in AIM-TD, a 12-Week Double-Blind, Placebo-Controlled Study
Objective: To assess the effect of deutetrabenazine (DTB) on quality of life (QoL) of patients with tardive dyskinesia (TD) as measured by the modified Craniocervical…D2 receptor mediated DARPP32/PP1α signaling is responsible for cadmium induced Parkinson’s like behavioral alterations in rats
Objective: To identify the specificity of dopamine D2 receptor mediated signaling in cadmium mediated motor alterations Background: Cadmium, a heavy metal, is to known to…Genetic and Clinical Analysis of Cerebral Calcifications
Objective: Genetic and clinical analysis in primary cerebral calcification. Background: Cerebral calcification is associated with a variety of disorders of different aetiologies. To date, the primary…Spastic paraplegia type 4: a novel SPAST splice site donor mutation and expansion of the phenotype variability
Objective: The aim of this study is to reveal molecular pathogenicity and genotype-phenotype correlations in spastic paraplegia type 4 (SPG4). Background: Mutations in SPG4/SPAST represent…Juvenile Huntington Disease (JHD) subjects’ stratification according to the mutation-length
Objective: To identify clinical and genetic markers to differ JHD from adult Huntington disease (HD) and to monitor JHD progression Background: JHD is a HD…Dynamic prediction of motor diagnosis in Huntington’s disease using a joint modeling approach
Objective: Compare various clinical and biomarker trajectories for tracking Huntington's disease (HD) progression and predicting motor conversion. Background: Huntington’s disease (HD) is a fatal neurodegenerative disease…Synthesis and pharmacological evaluation of 16-aryldieno steroids as anti-parkinsonian agents in LPS induced Neuroinflammation Model of Rat
Objective: The present study is aimed at design and synthesis of new therapeutically useful steroidal neuroprotective derivatives as anti-parkinsonian agents. The new 16-aryldieno steroidal derivatives…Role of the subthalamic nucleus and globus pallidus internus in response inhibition during masked prime tasks in human
Objective: To study the subthalamic nucleus (STN) and globus pallidus internus (GPi) local filed potential (LFP) activities in the response inhibition during masked prime tasks…
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