Key clinical milestones 15 years and onwards after DBS-STN surgery – a retrospective analysis of patients that underwent surgery between 1993 and 2001
Objective: In this paper we investigated patients with advanced Parkinson's disease (PD) operated at our center with subthalamic nucleus deep brain stimulation (STN-DBS) for at…Dynamics of subthalamic nucleus beta bursts in Parkinson’s disease during ON and OFF dopaminergic state
Objective: To investigate the dynamics of beta bursts in subthalamic nucleus (STN) local field potentials (LFP) in patients with Parkinson’s disease (PD) before and after…Clinical utility of chronic directional subthalamic Deep Brain Stimulatoin in Parkinson’s Disease
Objective: Here, we present our 3-month clinical experience with subthalamic directional DBS in treating Parkinson’s disease (PD) symptoms. Background: Directional Deep Brain Stimulation (DBS) is…Twiddler Syndrome in Deep Brain Stimulation
Objective: Twiddler syndrome is one of the major complications in DBS treatment. Background: The patient intentionally and subconsciously spins internal pulse generator Spinning generally causes…Effect of Deutetrabenazine on Quality of Life in Patients With Tardive Dyskinesia in AIM-TD, a 12-Week Double-Blind, Placebo-Controlled Study
Objective: To assess the effect of deutetrabenazine (DTB) on quality of life (QoL) of patients with tardive dyskinesia (TD) as measured by the modified Craniocervical…D2 receptor mediated DARPP32/PP1α signaling is responsible for cadmium induced Parkinson’s like behavioral alterations in rats
Objective: To identify the specificity of dopamine D2 receptor mediated signaling in cadmium mediated motor alterations Background: Cadmium, a heavy metal, is to known to…Genetic and Clinical Analysis of Cerebral Calcifications
Objective: Genetic and clinical analysis in primary cerebral calcification. Background: Cerebral calcification is associated with a variety of disorders of different aetiologies. To date, the primary…Spastic paraplegia type 4: a novel SPAST splice site donor mutation and expansion of the phenotype variability
Objective: The aim of this study is to reveal molecular pathogenicity and genotype-phenotype correlations in spastic paraplegia type 4 (SPG4). Background: Mutations in SPG4/SPAST represent…Juvenile Huntington Disease (JHD) subjects’ stratification according to the mutation-length
Objective: To identify clinical and genetic markers to differ JHD from adult Huntington disease (HD) and to monitor JHD progression Background: JHD is a HD…Dynamic prediction of motor diagnosis in Huntington’s disease using a joint modeling approach
Objective: Compare various clinical and biomarker trajectories for tracking Huntington's disease (HD) progression and predicting motor conversion. Background: Huntington’s disease (HD) is a fatal neurodegenerative disease…
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