Modeling Parkinson’s disease pathology by combined injection of fibrilar and monomeric α-synuclein in rat brain
Objective: Development of a fast and progressive Parkinson’s disease (PD) model in rat Background: α-Synuclein is a common link between sporadic and familial PD. Rodent…Successful passive monitoring of early-stage Parkinson’s disease patient mobility in Phase I RG7935/PRX002 clinical trial with smartphone sensors
Objective: Smartphone-based assessments and sensors have the potential to enable remote, passive monitoring of gait and mobility in early-stage Parkinson’s disease (PD) patients. Such sensor…Parkinson’s Disease-Like Pathology in the Rat Brain and Colon Following Methamphetamine Self-Administration
Objective: To determine if Parkinson’s disease (PD)-like pathology occurs in brain and colon following termination of methamphetamine (meth) self-administration. Background: Meth abuse increases the risk…Inhibition of mitochondrial complex I synthesis by chloramphenicol mitigates dopaminergic neuronal cell loss in PQ-induced parkinsonism
Objective: To find the potent drug for prevention of PD, we screened with above 1000 drugs in the PQ treated cells which currently used drug…Salivary Alpha-Synuclein in Aging
Objective: We measured alpha-synuclein total (a-syntotal) and alpha-synuclein oligomers (a-synolig) concentration in 70 healthy subjects, of different ages (from 18 to 88 years old) to…Insulin Resistance In Non-Diabetic People With Parkinson’s Disease
Objective: To study the incidence of insulin resistance (IR) in people with Parkinson's Disease (PD) and its relationship with motor and non-motor symptoms of the…Perrault syndrome: CLPP-Knock-Out mouse brain shows accumulation of mitoribosomes
Objective: We aimed to document the alterations of pathways and molecules that underlie brain pathology in the Perrault syndrome. Background: Perrault syndrome is an autosomal…Familial Creutzfeldt-Jakob Disease with an E200K Mutation in Peru: A Case Report
Objective: To describe the clinical and molecular features of a familial Creutzfeldt-Jakob Disease (fCJD) case in Peru. Background: Creutzfeldt - Jakob disease (CJD) is characterized…Reliability of Continuous Parkinson’s Assessment Using Wearables
Objective: To evaluate test-retest reliability and determine the optimal number of days of use for wearable sensors and a mobile software app to continuously and…Instrumental Measurement of Stepping in Place – Detection of Asymmetry and Freezing of Gait
Objective: To detect freezing of gait (FoG) and quantify movement asymmetry from markerless full body motion capture with Microsoft Kinect™ during the execution of a…
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