Inhibiting sphingosine-1-phosphate lyase as a possible therapy in Huntington’s disease
Objective: To advance our understanding of the process by which the mutant huntingtin (mHTT) protein contributes to neurodegeneration and translate that knowledge to potentially effective disease…Social hindrances for diagnosing Huntington’s disease
Objective: The need to differentiate the malingering from real complains Careful history can give a strong clue for the diagnosis Criminals can have diseases also…GBA mRNA is diminished in brain and blood of Lewy body diseases
Objective: To find out whether GBA deficiency starts at the transcriptional level and if it also involves alternative splicing. To study GBA expression changes in…Neuroprotective Potency of Tetrahydroisoquinoline a Novel Ayurveda Molecule in Experimental Parkinson’s Disease
Objective: Tetrahydroisoquinoline (TIQ) an identified alkaloid from ancient Indian ‘Ayurveda’ medicine for Parkinson’s disease (PD) was tested for neuroprotection in a cellular system and a…Relationship of metabolic markers in Parkinson’s disease
Objective: To investigate the relationship of obesity, Hypertension (HTN), Ischemic heart disease (IHD), Dyslipidemia (DLP), and Diabetes Mellitus (DM) with PD. Background: Parkinson’s disease (PD)…Impaired intracortical inhibition is associated with reduced hand dexterity in Parkinson’s disease patients
Objective: To check whether hand dexterity in Parkinson’s disease (PD) patients is linked with motor cortex excitability and plasticity. Background: Hand dexterity is impaired in…Expression of late cell cycle markers in Parkinson Disease and Lewy Body Dementia
Objective: The objective of this study is to determine the expression of late cell cycle markers in Parkinson Disease (PD) and Lewy Body Dementia (LBD) Background:…Objective gait parameters as a noninvasive biomarker for freezing of gait in Parkinson’s disease patients
Objective: To determine if steady-state gait parameters in Parkinson disease (PD) patients could serve as a predictive biomarker for freezing of gait (FOG). Background: FOG…Inhibition of long term memory and induction of biochemical deficits in rats following protofibrillar Aβ 1-42 injection
Objective: The present study was undertaken to study the effects of single intracerebroventricular (i.c.v.) injection of protofibrillar Aβ 1-42 on the long term memory Background:…An unusual presentation of tyrosine hydroxylase deficiency
Objective: To discuss a case of tyrosine hydroxylase deficiency presenting with resolution of symptoms on levodopa except for a dynamic segmental dystonia Background: Dopa-responsive dystonia…
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