Baseline predictors for clinical progression after 48 month follow-up in early Parkinson’s disease from the DeNoPa cohort
Objective: To analyze clinical progression at enrolment in drug-naïve Parkinson’s disease (PD) subjects over 48 months of follow-up, we describe the annual rate of progression…The Pull Test in healthy subjects and Parkinson´s disease: quantitative pull-force measure, postugraphic and electromyographic analysis
Objective: To study and compare in healthy subjects and patients with Parkinson´s disease (PD) the destabilizing force needed to reach the limit of stability (LoS), the displacements of…A combined cognitive and motor exercise program for people with Parkinson’s disease and Freezing of gait; a pilot study.
Objective: The purpose of this pilot study was to explore whether this combined cognitive and motor exercise program would 1) improve freezing of gait (FOG)…Active Arms: a randomized controlled trial of an interactive videogame for people with Parkinson’s disease
Objective: To determine if home-based exergames targeting the upper extremities (UE) improves arm and hand activities and impairments in people with PD. To establish the…Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson’s Disease Reduces the Risk of Polypharmacy: Five-Year Analysis
Objective: To compare the proportion of subjects on polypharmacy after five years in the deep brain stimulation (DBS) in early stage Parkinson’s disease (PD) pilot…Automated dosing schemes for administration of microtablets of levodopa for Parkinson’s disease, using wearable sensors
Objective: The aim of this study is to investigate the feasibility of using a dose optimization algorithm for dose individualization of microtables of levodopa. Background:…Evaluation of rotigotine transdermal patch in combination with low or high dose levodopa in patients with Parkinson’s disease: post-hoc analysis
Objective: To investigate the value of adding the dopamine agonist (DA) rotigotine (RTG) to low (<400mg/day) or high (≥400mg/day) levodopa (Ldopa) doses in patients with…ND0701: A new concentrated formulation of Apomorphine for continuous subcutaneous administration – human PK data
Objective: To evaluate the PK and relative bioavailability of ND0701, a subcutaneously (SC) infused apomorphine-base product candidate, and a commercial apomorphine-HCl product. The secondary objective…Improvement in attention/memory domains in advanced Parkinson’s disease patients treated with levodopa-carbidopa intestinal gel is associated with better quality of life
Objective: To evaluate the relationship between non-motor symptom (NMS) severity, quality of life (QoL), and activities of daily living (ADL) in advanced Parkinson’s disease (PD)…The effect of early STN-DBS in PD patients on axial symptoms: a 2-year randomized controlled trial (EARLYSTIM-Gait analysis)
Objective: This study assesses the effect of STN-DBS in early PD patients on axial symptoms compared to BMT. Background: In well-selected candidates, STN-DBS offers symptom…
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