How to switch from Entacapone to Opicapone based on BIPARK-I study experience
Objective: To clarify how easily can entacapone (ENT) be switched to opicapone (OPC), in levodopa-treated patients with Parkinson’s disease (PD) and motor-fluctuations. Background: OPC, a…Medical Treatment Termination in Parkinson’s Disease Patients after Hepad Therapy: A Case Series
Objective: To report seven clinical cases of treatment completion and improvement of symptoms after a PD therapy regimen that included Hepad. Background: DOPA decarboxylase inhibitor…Hypometabolism in Orbitofrontal and Perirhinal Cortex is Associated with Impulse Control Disorder in Parkinson´s Disease
Objective: (i)To elucidate the metabolic correlates sub-serving the clinical expression of ICD in PD and (ii) to evaluate the association between the glucose metabolism and…Aberrant resting state functional brain networks in patients with Parkinson’s disease and visual hallucinations
Objective: To explore the neural correlates of Visual Hallucinations (VH) in patients with Parkinson’s disease (PD). Background: Psychosis is one of the commonly observed non-motor…Resting state functional connectivity in PD patients with and without Freezing of gait
Objective: To investigate resting state functional connectivity (rsFC) abnormalities in patients with Parkinson's disease (PD), either with (PD-FOG) or without freezing of gait (PD no-FOG). …Early caudate involvement in Parkinson’s disease may predict future cognitive decline
Objective: 1. To investigate prevalence of caudate dopaminergic dysfunction as measured by 123I-FP-CIT in a large cohort of early stage (< 2 years disease duration)…Altered Resting-State Functional Interhemispheric Connectivity in Parkinson’s Disease
Objective: To examine direct interhemispheric functional connectivity (FCi) in Parkinson's disease (PD) during resting-state fMRI and to investigate the relations between observed connectivity changes and…Assessing cholinergic innervation in Parkinson’s disease using the PET imaging marker [18F]Fluoroethoxybenzovesamicol
Objective: To validate [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV) imaging in healthy volunteers by dynamic scanning. The secondary objective of this study was to evaluate the differences in [18F]FEOBV binding…Non-motor symptom burden is associated with thalamic atrophy in Parkinson’s disease
Objective: To investigate whether non-motor symptoms burden is associated with cortical and subcortical morphological changes in PD patients. Background: Non-motor symptoms are common aspects of…Pilot evaluation of pseudoelastic orthoses for supporting motor control in children with secondary dystonia and dyskinesia
Objective: The study reports preliminary observations on the use of orthotic devices with nonlinear spring properties prescribed with the aim to stabilise posture and improve…
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