Differential microRNA expression in a cohort of Parkinson’s disease patients
Objective: To develop a blood test that will use micro RNA (miRNA) to identify patients with PD Background: PD is a progressive neurodegenerative disorder and…Parkinsonism through astrocytic GABA induce motor symptoms
Objective: Although reactive gliosis is a prominent feature of PD, its role in pathogenesis has remained elusive. Here we show that aberrantly synthesized GABA from reactive astrocytes tonically inhibits neighboring dopaminergic neuronal firing in SNpc, reducing dopamine production and release, leading to parkinsonian motor symptoms. Background: Parkinsonism is a clinical syndrome of movement abnormalities seen in Parkinson’s disease (PD), which has been attributed to cell-autonomous mechanism of doparminergic neuronal death in the substantia nigra pars compacta (SNpc). Methods: To identify the…Progressive Supranuclear Palsy : About one case at the Neurology Department – Dakar
Objective: We report an observation of a case received at the consultation in the Neurology Department of National Teaching Hospital Fann. Background: Progressive supranuclear palsy…An unusual mimicker of Lewy Body Dementia: Gliomatosis Cerebri.
Objective: Report a case of rapidly progressive dementia and parkinsonism related to gliomatosis cerebri. Background: Neoplasms may present as parkinsonian syndrome due to impairment of…Quality of Life in Homebound People with Advanced Parkinson’s Disease: Feasibility and Outcomes of an Interdisciplinary Home Visit Program
Objective: 1) To demonstrate the feasibility of an interdisciplinary home visit program (HVP) for advanced Parkinson’s disease (PD) providing expert, interdisciplinary care directly to homebound…Changes in Functioning Associated with Exercise in Individuals with Parkinson’s
Objective: The purpose of this study was to assess changes in physical function, cognitive function, and quality of life in individuals with Parkinson’s disease as…SweetSpot of antidystonic effect in pallidal neurostimulation: a European multicentre imaging study
Objective: We investigated Volumes of Tissue activated (VTA) in dystonia subjects under DBS. We aimed to disentangle the SweetSpot for dystonia suppression within the pallidal region.…Safety and tolerability of deep brain stimulation in early stage Parkinson’s disease: Five-year follow-up of medication use and adverse events
Objective: To evaluate the long-term safety and tolerability of subthalamic nucleus deep brain stimulation (DBS) for early stage Parkinson’s disease (PD). Background: Twenty-nine subjects with…Deep Brain Stimulation for Parkinson’s disease: Short-term outcomes, referral patterns and health disparities.
Objective: To describe the practice patterns at University of Miami (UM), short term outcomes and health disparities among ethnic groups. Background: Deep brain stimulation (DBS)…UPDRS benefit from dual frequency DBS fields sculpted by intentionally overlapped interleaving
Objective: We show that UPDRS-III scores after interleaving compared to those prior to interleaving reflect a gain in benefit by lowered scores. Background: Previously, we…
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