Synthesis and pharmacological evaluation of 16-aryldieno steroids as anti-parkinsonian agents in LPS induced Neuroinflammation Model of Rat
Objective: The present study is aimed at design and synthesis of new therapeutically useful steroidal neuroprotective derivatives as anti-parkinsonian agents. The new 16-aryldieno steroidal derivatives…Role of the subthalamic nucleus and globus pallidus internus in response inhibition during masked prime tasks in human
Objective: To study the subthalamic nucleus (STN) and globus pallidus internus (GPi) local filed potential (LFP) activities in the response inhibition during masked prime tasks…High-mobility group box 1 from astrocytes upregulates TH expression to maintain dopaminergic neurons via JNK pathway in human Parkinson’s disease patients and MPTP induced mouse model
Objective: Supporting by glial cells could be reinforced the function of dopaminergic neurons against extracellular insults in Parkinson’s disease (PD) development. However, we do not…Correction of minimal oculomotor disorders improves forward and lateral axial dystonia in Pakinson’s disease
Objective: To evaluate the possible improvement of lateral and forward axial dystonia in PD patients following correction of minimal oculomotor abnormalities including version and saccades…CR6-interacting factor1 Deficiency in Dopamine Neurons Triggers Early-onset Parkinsonism in Mice
Objective: One candidate is CR6-interacting factor1 (CRIF1), which controls translation and membrane insertion of 13 mitochondrial proteins involved in oxidative phosphorylation. Here we determined the…In silico predictive analytics: accelerating identification of potential disease-modifying compounds for Parkinson’s disease
Objective: To use an in silico screen to identify compounds that have potential to reduce α-synuclein (aSyn) oligomers and are amenable to drug repurposing for…Vitamin D in the Parkinson’s Associated Risk (PARS) Study
Objective: The purpose of this study was to evaluate vitamin D levels in a population at risk for developing Parkinson’s disease (PD). Background: Vitamin D…Saccadic impairment in patients with Gaucher’s disease type 3
Objective: To characterize saccades in patients with chronic neuronopathic Gaucher’s disease (GD3) in relationship to their neurological and cognitive status using a computer-based eye-tracking technique. Background: GD3 is…A Pair of Brothers with Aceruloplasminemia Due to a Novel Nonsense Mutation: Unusual Phenotype and Neurological Improvement After Iron-Chelation Therapy with Deferasirox.
Objective: We describe the phenotype of a novel ceruloplasmin mutation and the neurological response to different iron-chelating therapies. Background: Aceruloplasminemia (AC) is a rare autosomal…Gait, Freezing of Gait and Falls detection using wearable sensors; a systematic review
Objective: An overview of the use of wearable systems to assess gait, freezing of gait (FOG) and falls in patients with Parkinson’s disease (PD). Background:…
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