Disease-modification in Translational Models of Parkinson’s disease by the Rho Kinase Inhibitor Fasudil
Objective: To evaluate the therapeutic potential of the Rho Kinase (ROCK) inhibitor Fasudil in translational models of Parkinson’s disease (PD). Background: There is still a…Analysis of serum non-mercaptoalbumin in patients with Parkinson’s disease
Objective: It is well known that the oxidative stress might be associated with the pathomechanisms of Parkinson’s disease (PD). In this study, we assessed serum…Feasibility and Safety of Multisite Tissue and Biofluid Sampling for Alpha-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Objective: The S4 study aims to characterize the distribution of alpha-synuclein (aSyn) pathology in multiple tissues and body fluids within the same Parkinson’s disease (PD)…Evaluation of spike sorting algorithms applied to artificial spikes and to spikes recorded from the Subthalamic Nucleus of PD patients
Objective: To evaluate the variability in spike sorting results using different clustering algorithms Background: Extracellular currents recorded from the Subthalamic Nucleus (STN) of PD patients,…Anti-synuclein alpha antibodies and IL-1β at Parkinson Disease (PD).
Objective: Determine a correlation between the levels of anti-synuclein alpha antibodies and IL-1β at serum and CSF of patients with PD. Background: PD is a…Neuroprotective effect of α-Mangostin in restoration mitochondrial function in MPTP-Induced Parkinson’s disease in mice
Objective: The aim of the present study was to explore the protective effect of alpha-mangostin against mitochondrial oxidative stress in MPTP treated mice. Background: It…Freezing of gait in Parkinson’s disease consists of unique pressure-based gait phase transitions
Objective: To develop a method to detect freezing of gait in real time Background: Freezing of gait (FOG) is a major debilitating symptom and cause…Assessments of Movement Disorder Symptoms and Functional Impacts in Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)
Objective: To identify Clinical Outcome Assessments (COAs) appropriate for the evaluation of paroxysmal movement disorder symptoms and functional impact in Glut1 DS. Background: Glut1 DS…Manifestations of restless legs syndrome and its influence on the clinical course of associated migraine
Objective: to study the development of restless legs syndrome in advanced stage of migraine. Background: Restless legs syndrome is relatively rare sensorimotor disorder, characterized by…Non-Invasive Assessment of Swallowing and Respiration Coordination in Early Parkinson’s Disease
Objective: To investigate swallowing and its coordination with respiration in patients with Parkinson’s disease. Background: Patients with Parkinson’s disease usually present with speech and swallowing…
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