Effect of food on Opicapone pharmacokinetics and pharmacodynamics
Objective: To characterize the effect of food on the pharmacokinetics (PK) and pharmacodynamics (PD) of opicapone (OPC) after single and repeated doses. Background: OPC, a…Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson’s disease
Objective: To employ a combination of elemental concentrations in the cerebrospinal fluid (CSF) to identify a diagnostic biomarker profile differentiating patients with idiopathic Parkinson´s disease…Relationship between non-motor symptoms and dopamine transporter activity in Parkinson’ s disease
Objective: We investigated whether dopamine transporter single-photon emission computed tomography (DAT-SPECT) binding correlates to non-motor symptoms in patients with Parkinson’s disease (PD). Background: DAT-SPECT binding…Dopamine transporter imaging predicts motor response to dopaminergic therapy for patients with advanced Parkinson’s disease: Possible role in patient selection for subthalamic deep brain stimulation.
Objective: To investigate the possible role of dopamine transporter (DAT) imaging in patient selection for subthalamic deep brain stimulation (STN-DBS) surgery, we retrospectively investigated the…Longitudinal comparison of 11C-PE2I and 18F-DOPA PET for assessing severity and rate of disease progression in patients with Parkinson’s disease
Objective: To directly compare 18F-DOPA with a highly specific dopamine transporter radioligand 11C-PE2I, for the assessment of motor severity and rate of progression in Parkinson's…Neural correlates of minor hallucinations in Parkinson’s disease: A multimodal imaging study
Objective: To explore the neural correlates sub-serving isolated minor hallucinations in Parkinson's disease (PD) through a multimodal structural and functional neuroimaging approach based on grey matter…Dopamine Normalizes Putamen to Insula Activation Shift During Choice Reaction Time Task in PD
Objective: We investigated Parkinson’s disease (PD) patients during a functional MRI Choice Reaction Time (CRT) task and determined whether brain activations are altered by dopamine. Background:…High-Pass Filtered Phase MR Imaging to Detect Longitudinal Motor Associations of Iron Accumulation in Parkinson’s Disease
Objective: To assess whether longitudinal changes in deep grey matter nuclei iron content are associated with declining motor function in Parkinson’s disease over a period…Exercise alters response of reward anticipation in the ventral striatum of subjects with Parkinson’s disease
Objective: To investigate the effects of exercise on reward circuitry in Parkinson’s disease (PD). Background: The benefits of exercise in PD have been linked to…Palmaris Brevis Spasm:A rare cause of paediatric movement disorder
Objective: Case report of paediatric Palmaris Brevis Spasm (PBS) Background: PBS is a rare movement disorder causing intermittent twitching of the palmaris brevis muscle. This muscle…
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