Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective:
We investigated whether dopamine transporter single-photon emission computed tomography (DAT-SPECT) binding correlates to non-motor symptoms in patients with Parkinson’s disease (PD).
Background:
DAT-SPECT binding at striatal presynaptic terminals is associated with the loss of functional neuronal activity, and correlates with duration and severity of motor features in PD. Regarding relationship between non-motor symptoms and striatal DAT availability, the association of DAT-SPECT binding with apathy in untreated and non-depressed de novo PD patients has also been reported. In addition, anosmic patients with PD showed the decreased striatal [123I]β-CIT binding.
Methods:
Forty patients with PD were evaluated to DAT-SPECT, motor and non-motor functions by MDS-UPDRS I, II, III, Odor Stick Identification Test for Japanese (OSIT-J), REM sleep behavior disorder (RBD) Screening Questionnaire of Japanese version (RBDSQ-J), and Single-Question Screen (RBD 1Q).
Results:
DAT binding had negative correlations with age, scores of MDS-UPDRS I, II and III (p < 0.01, 0.001, 0.05). Subcategories on MDS-UPDRS I; sleep, constipation and pain were significantly correlated with DAT binding (p < 0.01). There was not any correlation between scores of OSIT-J, or RBDSQ-J and DAT binding.
Conclusions:
DAT binding correlated not only motor symptoms but also to some non-motor symptoms in PD.
References: 1) Ba F, Martin WR. Parkinsonism Relat Disord. 2015;21:87-94. 2) Santangelo G, et.al. Parkinsonism Relat Disord. 2015;21:489-93
To cite this abstract in AMA style:
M. Iijima, H. Yoshizawa, Y. Uchiyama, K. Abe, K. Kitagawa. Relationship between non-motor symptoms and dopamine transporter activity in Parkinson’ s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/relationship-between-non-motor-symptoms-and-dopamine-transporter-activity-in-parkinson-s-disease/. Accessed November 10, 2024.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-between-non-motor-symptoms-and-dopamine-transporter-activity-in-parkinson-s-disease/