The identification of molecular-genetic background of familial atypical parkinsonism in “Hornacko”, a specific region of the south-eastern Moravia, Czech Republic.
Objective: To assess the genetic background in the pedigrees with identified autosomal-dominant inheritance of parkinsonism. Background: Increased prevalence of parkinsonism with cognitive deterioration was detected…Specific Bdnf variants are associated with suboptimal response to levodopa but not to other dopaminergic medications or deep brain stimulation in Parkinson’s disease
Objective: We examined the impact of rs6265 and other brain-derived neurotrophic factor (Bdnf) variants in two subject cohorts: 1) early-stage Parkinson’s disease (PD) subjects from…Baseline Clinical Predictors of Future Psychotic Symptoms in de novo Parkinson Disease
Objective: To determine which baseline clinical symptoms are associated with future psychotic symptoms in de novo Parkinson disease (PD). Background: Because psychosis in PD is…Impulse Control Disorders in Parkinson’s Disease: Prevalence and Clinical Features in the Rush University Movement Disorders Clinic
Objective: Investigate the prevalence and characteristics of Impulse Control Disorders (ICDs) in the PD population as compared to non-ICD patients in the Rush University Movement Disorders (RUMD) database.…Accuracy measures of imbalance bedside examination
Objective: This study explores the accuracy of bedside examinations used to screen for imbalance, using the Berg Balance Scale (BBS) as gold standard(cut-off point:45). Background:…Fatigue in Functional Motor Disorders.
Objective: To investigate fatigue severity and the nature of fatigue in functional motor disorders (FMD). Secondarily, to determine the relationship between fatigue, quality of life,…A Comparison of Muscular Atrophy Between Botulinum Toxin Types A and B
Objective: To compare and quantify the degree of muscular atrophy (MA) in botulinum toxin (BT) type A (Botox) and type B (Myobloc). A secondary endpoint…Effect of Personal Characteristics on Semiology of the First Tic Episode in Children with Tourette Syndrome
Objective: to determine the correlation between personal characteristics and semiology of the first tic episode in children with Tourette syndrome. Background: there is a lack…Motor and Body Composition Variables by Parkinson’s Disease Staging
Objective: Knowing the motor variables involved in the relationship of body composition and staging of disease. Background: Functional limitation, defined as a restriction in the…A Pilot Multiparametric MEG Study of coherence in generalized and cervical dystonia
Objective: To explore functional connectivity at network level with MEG, pre and post-administration of medications, in generalized and cervical dystonia. Background: The underlying mechanisms of…
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