Dynamic of symptoms of dopamine dysregulation syndrome after deep brain stimulation in patients with Parkinson`s disease
Objective: Assessment of the dynamics of dopamine dysregulation syndrome in patients with Parkinson`s disease after deep brain stimulation of the subthalamic nucleus compared with the…Tardive Dyskinesia by Body Region in Subjects with Schizophrenia/Schizoaffective Disorder or Mood Disorder: Findings from the KINECT 3 Study
Objective: To characterize dyskinesia distribution by body region in subjects with tardive dyskinesia (TD) enrolled in a clinical trial of valbenazine, based on baseline Abnormal…Tacrolimus induced parkinsonism presenting as freezing of gait and speech
Objective: Tacrolimus a calcineurin inhibitor is the most widely used immunosuppressant in post transplant patients. Mild adverse effects like tremors and parasthesia and occasionally major…Fragile X Gray Zone Alleles are associated with Higher Global Motor Function in an Elderly Community Population
Objective: To determine the association between FMR1 gray zone expansion and the presence of parkinsonism, motor, and cognitive function in community based individuals. Background: Larger expansions,…Down-regulation of miR-9* in the peripheral leukocytes of Huntington’s Disease patients
Objective: To determine whether the alterations of microRNA expression in central nervous tissues can be detected in peripheral leukocytes in Huntington's disease (HD) patients. Background: Huntington’s…Large CAG expansions in Huntington disease children: the RAREST-JHD initiative
Objective: RAREST-JHD (Juvenile Huntington Disease) is an initiative to study young HD subjects’ clinics, genetics and imaging to identify markers to transfer into clinics and…Prevalence of substance abuse in Huntington´s disease patients and its relationship with neuropsychiatric symptoms
Objective: To describe the prevalence of substance abuse and its relationship with neuropsychiatric features in Huntington’s disease (HD). Background: Substance abuse is not well established…Axial signs in early-stage Parkinson’s disease : an influence of the genotype ?
Objective: To assess the association between the genotype and the axial signs. Background: Regarding the onset of axial signs in Parkinson’s Disease (PD), heterogeneity has…Gait disturbance and olfactory dysfunction is associated with central cholinergic dysfunction in early Parkinson’s disease
Objective: We hypothesis that olfactory dysfunction, could be an independent predictor of gait disturbance in early PD. Background: The pathophysiology of gait disturbance is not fully…The tricyclic antidepressant medication nortriptyline inhibits alpha-synuclein accumulation, aggregation and toxicity in multiple in vitro and in vivo models.
Objective: Using preclinical models, assess the potential disease-modifying effects of nortriptyline (NOR) as a treatment in early Parkinson’s disease (PD). Background: PD and other synucleinopathies…
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