MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2018 International Congress

    Effect of different normative samples and cut-off values on determination of cognitive impairment in the Parkinson’s Progression Marker Initiative

    K. Wyman-Chick, D. Weintraub, P. Martin, L. Erickson, M. (Saint Paul, MN, USA)

    Objective: Compare cognitive performance in participants with Parkinson Disease (PD) utilizing published normative data versus age-stratified norms from the Parkinson’s Progression Marker Initiative (PPMI) healthy…
  • 2018 International Congress

    Opposite effects of dopamine on specific NoGo perfomance in young and late onset Parkinson’s disease and the relationship to nigrostriatal degeneration

    D. Kübler, H. Schroll, U. Scheller, R. Buchert, A. Kühn (Berlin, Germany)

    Objective: To investigate inhibitory control under dopamine (DA) in Parkinson’s disease (PD). Background: The pattern of degeneration in PD as well as side effects of…
  • 2018 International Congress

    Turning during gait is associated with gray matter density of the nucleus basalis of Meynert in Parkinson’s disease

    R. Morris, T. Madhyastha, D. Martini, K. Smulders, J. Quinn, V. Kelly, K. Edwards, C. Zabetian, T. Grabowski, F. Horak (Portland, OR, USA)

    Objective: To examine whether turning during gait is associated with gray matter (GM) density of the nucleus basalis of Meynert (nbM) and attention in people…
  • 2018 International Congress

    Early synaptic loss and synaptic instability in a mouse model of prodromal Parkinson’s disease

    Y. Hatanaka, R. Takahashi (Kyoto, Japan)

    Objective: In order to elucidate very early pathologis of Parkinson’s disease (PD), we focused on synaptic pathologies in a newly developed mouse model of prodromal…
  • 2018 International Congress

    Knockdown of eEF1A2 reduced neuronal survival in a SH-SY5Y cellular model of Parkinson’s disease through the PI3K/Akt/mTOR pathway

    K. Khwanraj, P. Dharmasaroja (Bangkok, Thailand)

    Objective: To investigate whether eEF1A2 promotes neuronal survival through PI3K/Akt/mTOR pathway in a toxin-induced Parkinson’s disease model. Background: Parkinson’s disease is a common neurodegenerative disorder…
  • 2018 International Congress

    Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) -mediated ubiquitination attributed to localization of Mortalin to mitochondria

    L. Wu, W. Yang, Y. Tan, J. Ding, S. Chen (Shanghai, China)

    Objective: The pathogenic mechanism of UCHL1 in PD remains unclear. In this study, we aimed to investigate the role of UCHL1 in the pathogenesis of…
  • 2018 International Congress

    Relationship between cyclooxygenase-2 gene polymorphisms and Parkinson’s disease susceptibility in Chinese Han population

    M. Ye, Y. Yao, H. Gao (Nanjing, China)

    Objective: To investigate relationship between the cyclooxygenase-2 (COX-2) gene promoter region (rs20417, rs689466, rs689465) and 3'untranslated region (rs5275) polymorphisms with Parkinson’s disease (PD) susceptibility in…
  • 2018 International Congress

    Frequency of the LRRK2 and GBA mutations in Russian population with Parkinson’s disease

    K. Senkevich, A. Emelyanov, M. Nikolaev, T. Usenko, A. Bezrukova, I. Miliukhina, A. Kopytova, A. Timofeeva, A. Yakimovsky, S. Pchelina (Saint-Petersburg, Russian Federation)

    Objective: To estimate the frequency of LRRK2 mutation (G2019S) and GBA mutations (N370S, L444P) and polymorphic variants (E326K, T369M) in PD and controls in the…
  • 2018 International Congress

    Association between MAPT haplotype and hippocampal repetition suppression in Parkinson’s disease

    E. Yoon, T. Alrazi, M. Ramezani, I. Kathol, J. Sarna, T. Hammer, L. Derwent, J. Cheetham, Z. Gan-Or, G. Rouleau, O. Monchi (Calgary, AB, Canada)

    Objective: We aimed to explore the relationship between the microtubule-associated tau gene (MAPT) haplotypes and response in the hippocampus to repeated stimuli in Parkinson’s disease…
  • 2018 International Congress

    Bupropion causing misdiagnosis in brain dopamine transporter imaging for parkinsonism

    E. Honkanen, N. Kemppainen, T. Noponen, M. Seppänen, J. Joutsa, V. Kaasinen (Turku, Finland)

    Objective: To report long-lasting effects of bupropion on brain dopamine transporter (DAT) binding in a patient with depression and parkinsonism. Background: Striatal DAT imaging is…
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