Nurr1 gene: A new research target for Parkinson’s disease
Objective: The objective of our study is to determine if Nurr1 gene, a transcription factor essential for dopamine (DA) neuron development and survival, is a…Polymorphisms of glutamatergic system genes are associated with levodopa-induced dyskinesia in Parkinson’s disease
Objective: We aimed to study the association between glutamatergic system gene polymorphisms (SLC1A2 – gene, coding excitatory acids transporter, and GRIN2A gene, coding a subunit…Genome-wide association studies of motor and cognitive progression in Parkinson’s disease
Objective: Motor and cognitive progression in Parkinson’s is heterogeneous. Our aim is to identify single nucleotide polymorphisms (SNPs) associated with disease progression. Background: Rare genetic…Daughter’s ataxia reveals father’s genetic Parkinsonism. The first reported case of Spinocerebellar ataxia -15 presenting with levodopa responsive hemi Parkinsonism
Objective: A 38 year old Australian florist of Anglo-Celtic origin described two years of difficulty using his right hand with associated sensory disturbance attributed initially…Substantia Nigra Echogenicity Associated with Clinical Subtypes of Parkinson’s Disease
Objective: We classified Parkinson’s disease (PD) patients into different subtypes and evaluated the correlation between the substantia nigra (SN) echogenicity and disease progression. Background: It…Brain Network Connectivity Measured by Diffusion Tensor Imaging Predicts Prognosis in Parkinson’s Disease
Objective: We aimed to explore whether network connectivity structure as measured by diffusion tensor imaging (DTI) are associated with progression rate of motor and non-motor…Quantification of the PD Motor Syndrome Using an Inclusive Score (PD9) Derived from Sensor Data with Deep Learning
Objective: To quantify the PD motor syndrome with increased temporal and severity granularity using non-invasive internet-of-things (IoT) devices and deep learning methods. Background: Brady-hypokinetic parkinsonistic…Neuromodulation by rTMS in Parkinsons Disease: A fMRI Study
Objective: To compare the efficacy of rTMS [when given at primary motor area (MA), pre-motor area (PMA), supplementary motor area (SMA)] in Patients with Parkinson’s…Cerebrospinal fluid protein biomarkers in PD patients after DBS-STN surgery: A retrospective analysis of patients that underwent surgery between 1993 and 2001
Objective: To investigate cerebrospinal fluid (CSF) markers of neurodegeneration [neurofilament light chain (NFL), total Tau (T-Tau)], tau pathology [phosphorylated tau (p-Tau)], glial cell damage or…Impaired topographic organization in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease
Objective: To investigate the disrupted topographic organization in a cohort of cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease (PDAR), and its potential relationships with…
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