ODM-104 and optimized carbidopa dose show beneficial effect on levodopa PK in healthy subjects
Objective: To study the dose effects of a novel catechol-O-methyl transferase (COMT) inhibitor ODM-104 and the aromatic L-amino acid decarboxylase (AADC) inhibitor carbidopa on levodopa…Safety and Efficacy of Levodopa-Carbidopa Monotherapy in Patients with Advanced Parkinson’s Disease
Objective: Evaluate efficacy/safety of levodopa-carbidopa intestinal gel (LCIG) daytime monotherapy (with/without nighttime oral carbidopa/levodopa) vs polytherapy (LCIG with >1 adjunctive therapy) in advanced Parkinson’s disease…Levodopa Induced Orthostatic Hypotension in Parkinson’s Disease: A Single-Dose Response Study
Objective: To determine the effect and risk factors of a single dose levodopa induced OH in PD Background: Levodopa (LD) is widely recognised as the…The outcome of directional subthalamic deep brain stimulation in advanced Parkinson’s disease
Objective: To assess the outcome of patients with advanced Parkinson’s disease (PD) treated with directional DBS. Background: Subthalamic deep brain stimulation (STN-DBS) has proved to…Dysphagia predicts poor outcome in late-stage Parkinson’s disease
Objective: to evaluate the clinical progression and prognostic factors of a late-stage PD (LSPD) population. Background: Parkinson’s disease (PD) disability milestones emerge in an exponential…Movement Disorders as Postinfectious Neurologic Syndromes
Objective: We shows the three patients which some neurologists diagnosed psychological disorders at first. Their movement disorders are due to postinfectious neurologic syndromes (Epstein-Barr virus…Movement disorders in mitochondrial disease: Radio clinical correlation in pediatric patients
Objective: Investigate the clinical features of movement disorders (MD), as well as brain imaging findings, in order to identify a radio-clinical correlation in mitochondrial diseases…Clinical characterization of tremor in patients with Phenylketonuria (PKU)
Objective: To assess the occurrence, age at onset, distribution, associated neurological signs and possible pathogenetic biomarkers of tremor in PKU. Background: PKU is an inborn…No deleterious effect of unilateral Gamma Knife thalamotomy on gait and posture in patients with essential tremor
Objective: We aimed to describe specific features of gait disorders and postural instability in patients with severe essential tremor (ET), and to evaluate the effect…Pallidotomy in dystonia –Experience from a tertiary care centre in a developing country
Objective: The objective of the present study was to determine the outcomes of pallidotomy in dystonia patients in a developing nation. Background: Pallidotomy is one…
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