A Study of Pain in Parkinson’s Disease
Objective: To study the prevalence, type and severity of pain in patients with Parkinson’s disease. Background: Pain is one of the recognised non-motor symptoms in…New evidence for thalamic dysfunction in Parkinsonian rats
Objective: Abnormal oscillatory activity within the cortico-basal ganglia (BG)-thalamo-cortical circuit has been observed in Parkinsonian state, especially of β and γ bands (βB and γB).…The difference in posture reaction against backward perturbation between patients with Parkinson’s disease and healthy controls
Objective: To investigate the posture reaction in patients with Parkinson’s disease (PD) and healthy age-matched controls when they were given quantitative backward perturbation. Background: Although…Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…Activation of chaperone-mediated autophagy reduces oligomeric alpha-synuclein accumulation in LRRK2(R1441G) knockin mouse model of Parkinson’s disease (PD)
Objective: To determine age-dependent accumulation of oligomeric alpha-synuclein in the brain of aged LRRK2(R1441G) knockin mice; and to explore whether activation of chaperone-mediated autophagy (CMA)…PrP as a receptor of alpha-synuclein in the pancreas of patients with synucleinopathies
Objective: We have investigated whether the cellular prion protein interacts with alpha-synuclein in pancreatic cells of patients with synucleinopathies. Background: Neurodegenerative diseases such as Alzheimer’s…Microglial activation, white matter and hippocampal damage correlate with cognitive impairment in chronic cerebral hypoperfused and MPTP-lesioned mice
Objective: We hypothesize that cerebral hypoperfusion may influence the cognitive function of PD animal models. To investigate the effects of cerebral hypoperfusion and microangiopathy on…Correlation between mood and behavioral disorders and quality of life in patients with Parkinson’s disease
Objective: The aim of this study was to investigate if the mood and behavioral disorders could be correlate with quality of life in patients with…Parkinson’s disease anxiety is associated with Lewy bodies in the Anterior Cingulate
Objective: The goal of this study is to determine if there is an association between anxiety and the presence and regional distribution of Lewy bodies…Dissociate effect of dopaminergic therapy in reward expectation and prediction error in PD patients with comorbid impulse control disorder
Objective: To study EEG oscillatory activity associated to reward prediction error in Parkinson’s disease (PD) patients with impulse control disorders (ICD) and determine how dopaminergic…
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