The FOsmetpantotenate Replacement Therapy (FORT) Pivotal Trial: Utilization of a Novel Primary Efficacy Outcome in Patients with Pantothenate Kinase-Associated Neurodegeneration
Objective: To describe the methodology and novel primary efficacy outcome measure in the ongoing pivotal FORT trial in patients with pantothenate kinase-associated neurodegeneration (PKAN). Background:…Development of evidence-based clinical practice guideline (CPG) of complementary and alternative medicine (CAM) for Parkinson’s disease (PD)
Objective: The purpose of this CPG was to describe the state of evidence on CAM interventions for PD reflecting current clinical practice. Background: Many patients…Review of mealtime difficulties following frontotemporal lobar degeneration
Objective: Aberrant eating behaviour and swallowing difficulties are reported in the conditions associated with frontotemporal lobar degeneration (FTLD) neuropathology. Here we review and summarize the…An oculogyric crisis after administation of alizapride: A tardive phenomenon?
Objective: We present a case of an oculogyric crisis (OGC) after administration of alizapride. Curious about this case is that the OGC only happened after…Deep Brain Stimulation of Globus Pallidus Internus Combined with Bilateral Anterior Capsulotomy for the Treatment of Tardive Dystonia in Patients with Refractory Schizophrenia
Objective: To evaluate the utility and safety of deep brain stimulation (DBS) of the globus pallidus internus (GPi) combined with bilateral anterior capsulotomy in the…The Adaptation of Card Games for Education in Movement Disorders
Objective: The objective of this project was to develop and use adapted interactive card games for education in movement disorders. Background: There is a clear…Compound-heterozygous mutations in VPS13D are a novel cause of spastic ataxia and lead to mitochondrial dysfunction
Objective: To identify the genetic cause in two sisters with spastic ataxia and to functionally characterize mitochondrial function in patient-derived cells. Background: Spastic ataxia is…Effect of Cold Compression Before Botulinum Neurotoxin Injection in Hemifacial Spasm
Objective: To compare effect of cold compression and no cold compression before Botulinum neurotoxin (BoNT) injection on severity, frequency of hemifacial spasm (HFS) and complication…Carbon Monoxide Poisoning-Induced Parkinsonism: A Prospective Study of Clinical and Neuroimage Correlation
Objective: To investigate prospectively the nigrostriatal system in patients with delayed post-anoxic Parkinsonism by TRODAT-1 brain SPECT serially and to correlate the neuropsychiatric performance and…Patterns of dopamine transporter imaging in subtypes of Multiple System Atrophy
Objective: To investigate the differences in the pattern of striatal (caudate and putamen) dopamine transporter(DAT) loss in a multiple system atrophy (MSA) cohort, based on…
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