A novel non-nitrocatechol COMT inhibitor ODM-104 shows superior pharmacodynamic effects to entacapone
Objective: ODM-104 is a novel non-nitrocatechol catechol-O-methyltransferase (COMT) inhibitor that is undergoing clinical evaluation for Parkinson’s disease (PD). This study investigated the pharmacodynamic effects of…Multimodal evoked potential analysis in Woodhouse-Sakati Syndrome
Objective: Investigate Woodhouse-Sakati syndrome through analysis of multimodal evoked potentials at various clinical stages, to assess their possible role as an aid in determining the…Movement disorder masquerading as seizure disorder
Objective: The main objective of presenting this case report is to emphasise the importance of accurate clinical diagnosis of movement disorder in children which many…Juvenile parkinsonism associated with a novel HSD17B10 mutation in a patient with HSD10 disease
Objective: We describe the case of a female patient with HSD10 disease associated with parkinsonism, with a novel mutation in the HSD17B10 gene. Background: HSD10…An early-onset parkinsonism revealing a Gaucher disease with a heterozygous mutation in GBA gene: A case report
Objective: To report a case of a late-onset Gaucher disease (GD) revealed by an atypical Parkinson disease. Background: GD is an autosomal recessive lysosomal disorder,…Effect of Thalamic Deep Brain Stimulation in Isolated Dystonia Associated with Prominent Tremor
Objective: To report the outcomes of a series of isolated dystonia patients with prominent tremor treated with thalamic deep brain stimulation (DBS). Background: Pallidal and…Optimized Imaging at 3.0 T of the Rostral Zona Incerta (rZI) for Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD)
Objective: To improve upon imaging of the rostral zona incerta (rZI) allowing for direct targeting during deep brain stimulation. Background: DBS of the subthalamic nucleus…Comparison of low-frequency stimulation versus high-frequency stimulation of the subthalamic nucleus on cerebral hemodynamics in Parkinson’s disease: A transcranial Doppler Study
Objective: Parkinson’s disease (PD) is the second most frequent progressive neuro-degenerative disease and the Deep Brain Stimulation (DBS) is a useful surgical treatment to treat…Intraparenchymal Cyst Formation: A Rare Complication of Deep Brain Stimulation
Objective: Intraparenchymal cyst formation after Deep Brain Stimulation (DBS) surgery is a rare complication. There are only 8 cases reported in the literature. We report…Dopaminergic medication changes affect cognitive, mood, and quality of life outcomes after STN DBS
Objective: To determine whether there is a relationship between dopaminergic medication reduction and cognitive, mood, or quality of life outcomes after STN DBS for PD.…
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