Oral treatment with JNX3001 protects dopaminergic function in a non-human primate model of Parkinson’s disease alpha-synucleinopathy
Objective: We evaluated the efficacy of JNX3001 in an aSyn-based macaque model with plasma exposures associated with efficacy in rodents. Background: Alpha-synuclein (aSyn) deposition is…Reduction of neuroinflammation by selective inhibition of the N-type calcium channel is beneficial in various animal models of neurodegeneration, here in the SOD1G93A transgenic mouse model of ALS
Objective: Neuroinflammation is a pathological hallmark of several neurodegenerative diseases. We speculated that reduction of calcium ion influx specifically in neurons should reduce inflammatory cellular…Rose Anthocyanins protect against Parkinson’s pathophysiology: Behavioral and biochemical changes in young Drosophila
Objective: To test the hypothesis that Rose Anthocyanins, owing to their biological properties in vitro, protect against Parkinson’s pathophysiology in young Drosophila melanogaster. Background: Anthocyanins…Oligosymptomatic Fahr’s syndrome (2 clinical cases)
Objective: Two clinical cases of Fahr`s syndrome was presented. Background: Fahr's syndrome (FS) or secondary bilateral striatopallidodentate calcinosis is a rare neurological disorder characterized by…Improvement in chorea and function in a patient with dystonia-choreoathetosis cerebral palsy after treatment with bilateral pallidal deep brain stimulation
Objective: We describe and demonstrate by video a patient with dystonia-choreoathetosis cerebral palsy treated with bilateral pallidal deep brain stimulation (DBS). Background: Dystonia-choreoathetosis cerebral palsy…Long term clinical outcome after deep brain stimulation of the thalamic VIM in Holmes Tremor: A case series
Objective: The clinical course and long term outcome up to 5 years post surgery of a sample of 4 patients with medical refractory HT who…Pulvinar low intensity on susceptibility-weighted imaging may predict cognitive worsening after deep brain stimulation therapy in Parkinson’s disease patients
Objective: This study was undertaken to predict cognitive worsening by pulvinar imaging in susceptibility-weighted imaging (SWI). Background: Deep brain stimulation (DBS) for Parkinson’s disease (PD)…Efficacy and safety of combined unilateral subthalamic nucleus and contralateral globus pallidus deep brain stimulation in Parkinson’s disease
Objective: To investigate the efficacy and safety of combined unilateral subthalamic nucleus (STN) and contralateral globus pallidus internus (GPi) deep brain stimulation (DBS) in Parkinson’s…Teed and primary cell longevity: Results from product surveillance registry
Objective: To evaluate the influence of electrical stimulation settings and impedance on primary cell IPG longevity in a global registry. Background: Deep Brain Stimulation (DBS)…Is lowering stimulation frequency a feasible option to improve speech in Parkinson’s disease patients undergoing subthalamic deep brain stimulation?
Objective: To analyzse the effect of low frequency (LFS) subthalamic nucleus deep brain stimulation (STN-DBS) on speech and voice in Parkinson’s disease (PD) patients with…
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