Movement and postural control in focal dystonia subjects measured using surface electromyography
Objective: To explore the difference in muscle activation during a postural versus movement control task in patients with focal dystonia. Background: Co-contraction of agonist and…Disease Modeling of Lesch-Nyhan Disease Using Induced Pluripotent Stem Cells
Objective: To create a resource of induced pluripotent stem cells (iPSCs) as models for exploring mechanisms of pathogenesis in Lesch-Nyhan disease (LND). Background: LND is…Prodromal features of Parkinson’s disease in women
Objective: To identify how prodromal features interact to determine Parkinson’s disease (PD) risk in women. Background: The neuronal loss that leads to PD progresses insidiously…Tendency towards being a “Morning person” increases risk of Parkinson’s disease: evidence from Mendelian randomisation
Objective: To explore the causal relationship between circadian rhythm and Parkinson's disease (PD), and coffee consumption and PD, using Mendelian randomisation (MR). Background: Circadian rhythm…Parallel evaluation of mutant huntingtin and neurofilament light in Huntington’s disease
Objective: To assess cerebrospinal fluid (CSF) mutant Huntingtin (mHTT), and CSF and plasma neurofilament light (NfL) in Huntington’s disease (HD). Background: HD is a progressive…Late onset Huntington’s disease in an Argentinian cohort
Objective: To describe the prevalence, clinical and molecular characteristics of a series of LOHD patients in an Argentinean cohort. Background: Late onset Huntington’s disease (LOHD)…Auto-antibodies and clinical-imaging associations in patients with Movements Disorders from a Neurological Institute in Mexico
Objective: Determine the prevalence of systemic and anti-neuronal antibodies in Movement Disorders patients from a third-level neurological hospital. Background: Autoimmunity is a common cause of…Metabolomic Profiling of Activated Microglial Cells
Objective: To investigate metabolomic changes in SIM-A9 microglia in vitro following exposure to neuroinflammatory insult using high resolution mass spectrometry. Background: Microglial cells play an…Dopaminergic neurons in Substantia Nigra pars compacta code the vigor of movement sequences
Objective: Assess the correlates of movement vigor in Substantia Nigra dopaminergic neurons Background: Current basal ganglia models have focused on the role of dopamine in…Acoustic, respiratory, cognitive and wellbeing comparisons of two groups of people with Parkinson’s disease participating in voice and choral singing group therapy (VCST) versus a music appreciation activity
Objective: The aim of this two armed RCT is to evaluate how intensive singing improves the phonatory and respiratory muscle control of people with Parkinson's…
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