Session Information
Date: Saturday, October 6, 2018
Session Title: Surgical Therapy: Parkinson's Disease
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To investigate the efficacy and safety of combined unilateral subthalamic nucleus (STN) and contralateral globus pallidus internus (GPi) deep brain stimulation (DBS) in Parkinson’s disease (PD).
Background: STN and GPi are two main target structures of DBS surgery for advanced PD patients who have medication-refractory motor complications. However, selection of the best DBS target for the treatment of advanced PD patients remains a matter of debate.
Methods: We retrospectively analyzed five PD patients who received combined unilateral STN and contralateral GPi (STN/GPi) DBS surgery. Clinical data of these PD patients were compared with those of 10 PD patients who received bilateral STN DBS surgery, and nine PD patients who received bilateral GPi DBS surgery. PD patients in each group were matched for age, sex, disease duration, daily levodopa equivalent dosage, and UPDRS scores before DBS surgery. Efficacy of DBS was evaluated postoperatively at one year using the Unified Parkinson’s Disease Rating Scale (UPDRS) under four different conditions of medication/stimulation-off and on status. Serious adverse effect of DBS was also assessed during the period of one year after DBS surgery.
Results: At one year after DBS surgery, there was no significant difference in the improvement of UPDRS total, part II, part III, and part IV scores of PD patients with STN/GPi DBS compared with those of PD patients with bilateral STN DBS or bilateral GPi DBS in the medication-on and stimulation-on state. This lack of difference of UPDRS scores among study groups was also observed in medication-off and stimulation-on status. The subscores of UPDRS for motor fluctuations (P=0.69) and dyskinesia (P=0.70) were also not different among three study groups. Serious adverse effect was also not different among study groups.
Conclusions: Our study results suggest that combined STN/GPi DBS for advanced PD patients may provide similar therapeutic effects and safety compared with bilateral STN or GPi DBS.
To cite this abstract in AMA style:
N.R. Choi, K.W. Park, H.S. Ryu, M.S. Kim, S.J. Chung. Efficacy and safety of combined unilateral subthalamic nucleus and contralateral globus pallidus deep brain stimulation in Parkinson’s disease [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/efficacy-and-safety-of-combined-unilateral-subthalamic-nucleus-and-contralateral-globus-pallidus-deep-brain-stimulation-in-parkinsons-disease/. Accessed May 24, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/efficacy-and-safety-of-combined-unilateral-subthalamic-nucleus-and-contralateral-globus-pallidus-deep-brain-stimulation-in-parkinsons-disease/