The establishment of Deep Brain Stimulation Nurse Association (DBSNA) in United Kingdom (UK)
Objective: This is a qualitative analysis in the establishment of DBSNA for specialist nurses working in neuromodulation in the UK. Background: Surgical movement disorder nurses…Intronic pentanucleotide TTTCA repeat insertion in SAMD12 gene causes familial cortical myoclonic tremor with epilepsy type 1
Objective: To identify the causative mutation in pedigrees with familial cortical myoclonic tremor with epilepsy (FCMTE) type 1. Background: FCMTE is an autosomal dominant neurodegenerative…New Nomenclature Of Genetic Myoclonus Syndromes
Objective: In collaboration with the International Parkinson and Movement Disorder Task Force for Nomenclature of Genetic Movement Disorders, we present a new classification of genetically…Exploring the neural correlates of gait asymmetry in idiopathic REM Sleep Behaviour Disorder
Objective: Given the typical asymmetric onset of motor symptoms in PD, the current study sought to investigate whether patients with iRBD show evidence of asymmetric…Safinamide inhibition of in vivo glutamate release in a rat model of Parkinson’s Disease
Objective: To evaluate whether safinamide inhibits in vivo glutamate (Glu) release in a rodent model of Parkinson’s disease (PD), i.e. the 6-hydroxydopamine (6-OHDA) hemilesioned rat.…The Small Molecule Alpha-Synuclein Misfolding Inhibitor, NPT200-11, Produces Multiple Benefits in an Animal Model of Parkinson’s Disease
Objective: To evaluate effects of NPT200-11 on Parkinson’s disease (PD)-relevant outcomes including alpha-synuclein pathology, neurodegenerative markers and motor performance in transgenic mouse models of PD.…Effect of lidocaine injection into the external oblique muscle on camptocormia and the lateral slant posture in patient with Parkinson’s disease
Objective: Camptocormia (CC) is one of the abnormal posture of Parkinson's disease (PD) patients, described as a severe forward flexion of the trunk. In this…Efficacy and safety of safinamide as a levodopa adjunct in patients with parkinson disease and motor fluctuations: A systematic review of randomized controlled trials
Objective: To assess the efficacy and safety of safinamide as an add-on therapy to levodopa in Parkinson patients. Background: Long-term use of levodopa is associated…Efficacy of sublingual apomorphine film (APL-130277) for the treatment of OFF episodes in patients with Parkinson’s disease: Results from the Phase 3 double-blind, placebo-controlled trial
Objective: To evaluate the efficacy of APL-130277 (APL) in a double-blind, placebo-controlled trial. Background: OFF episodes are a common, disabling complication of Parkinson’s disease (PD)…Inhibition of HDAC4 attenuates rotenone-induced abnormal increase of α-synuclein levels and affects autophagic flux in human dopaminergic SH-SY5Y cells
Objective: To explore the effects of selective inhibition of HDAC4, on levels of α-syn and autophagy-related proteins in PD. To discuss the mechanism for the…
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