Pharmacokinetics of ABBV-951 Following 24-Hour Continuous Subcutaneous Infusion to Arm, Abdomen and Thigh
Objective: Characterize levodopa pharmacokinetics (PK) and safety/tolerability of ABBV-951 in healthy volunteers at 3 different subcutaneous (SC) infusion sites: Arm, Abdomen and Thigh Background: As…Increased lysosphingolipids levels in blood of patients with multiple system atrophy
Objective: To estimate activity of lysosomal enzymes and lysosphingolipids concentration in dry blood spot of patients with synuleinopathies: Parkinson’s disease (PD), dementia with Lewy bodies…Neuromodulatory potentials of revasterol and Carpogon capitatus Roxb on the rat brain: Novel approach for Parkinson’s diseases
Objective: The aim of the current study is to explore the synergistic effects of revasterol and Carpogon capitatus extract Roxb in rotenone induced rat model…Gait impairment in Parkinson’s Disease: An [123I]FP-CIT SPECT study
Objective: To evaluate the association between gait impairment and striatal dopamine terminals and assess the hypothesis that gait impairment correlates with disease progression in de…A characterization of the ADL-level in daily life with Parkinson`s Disease based on objective measurements and subjective experiences.
Objective: 1. Test whether slow response to the medication and EMO-periods (Early Morning Off), affects the patient`s experience of being able to perform ADL-functions. 2.…Hoover’s Sign in Parkinson’s Disease
Objective: To study applicability of Hoover's sign to diagnostics of functional component in PD. Background: It has been reported that Parkinson’s Disease (PD) patients have…Osteopathic Manipulative Medicine to Improve Balance and Quality of Life in Parkinson Disease
Objective: To examine the effects of Osteopathic Manipulative Medicine (OMM) using a pre-defined protocol for 6 weeks and compare that to a 6-week counseling protocol…Ambroxol treatment of primary macrophages derived from patients with GBA-associated Parkinson’s disease
Objective: The aim was to evaluate the effectiveness of the restoration of GCase activity in macrophages from GBA-PD patients using pharmacological chaperone ambroxol. Background: Mutations…MDS-UPDRS Part III predictors of Part II Item Scores in PPMI
Objective: To identify the items in Part III of the MDS-UPDRS scale that are predictive to Part II items in early PD patients. Background: It…A cortical signature of motor response to dopaminergic therapy in Parkinson’s disease
Objective: To investigate whether cortical oscillations involved in sensorimotor processes might predict motor symptom response to dopaminergic treatment (MSRD) in Parkinson’s disease (PD). Background: MSRD…
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