Impaired lysosomal catabolism of alpha-synuclein in parkinsonian LRRK2(R1441G) mutant mouse embryonic fibroblasts
Objective: Using a unique fluorescence-based flow cytometry assay on LRRK2(R1441G) mutant mouse embryonic fibroblasts (MEFs) to elucidate whether pathogenic LRRK2 mutation affects cellular lysosomal degradation…Concomitant brain pathologies have no major impact on clinical milestones in progressive supranuclear palsy
Objective: To analyze the frequency and severity of co-pathologies in PSP patients and their relevance for the clinical presentation and progression in PSP. Background: The phenotypic…Progressive Parkinsonism and Cognitive Changes: A Rare Presentation of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)
Objective: To describe a rare manifestation of a case of CLIPPERS with video-based documentation of treatment responsiveness. Background: CLIPPERS is a rare inflammatory disease of…Comorbid Parkinson’s disease and Myasthenia Gravis: A Case-Control Study
Objective: To evaluate the clinical features of patients with Parkinson’s Disease (PD) with versus without comorbid Myasthenia Gravis (MG). Background: The recognition of the co-occurrence…High-throughput screening using a Drosophila model of Parkinson’s disease
Objective: To identify potential therapeutic compounds for Parkinson’s disease (PD) treatment by combining a phenotype-based high-throughput screening assay in PD model flies with a validation…Role of APOE ε4 status and Sex on Somatosensory Integration and Dual-Task Cost in Parkinson’s disease
Objective: To determine whether ε4 status relates to impaired somatosensory integration deficits in males more than females in people with Parkinson’s disease (PwPD). Background: Previous…Healthcare disparities in patients with Parkinson’s disease: A comprehensive literature review and call to action
Objective: To review the literature on healthcare disparities in Parkinson’s care in the United States and to initiate a community education program targeted at an…Diplopia and visual complaints in non-demented patients with Parkinson disease: a Japanese single center cross-sectional survey
Objective: To investigate the characterization of diplopia and visual complaints including minor forms of hallucinations (mHals) in non-demented patients with Parkinson disease (PD). Background: Double…Differences in resting state fMRI distinguish multiple system atrophy and Parkinson disease
Objective: To investigate whether functional connectivity of the hypothalamus can distinguish multiple system atrophy from Parkinson disease. Background: Multiple system atrophy parkinsonian subtype (MSA-P) and…Improving neuroprotective effects of resveratrol by brain targeting through chitosan glutamate nanoparticles in MPTP induced parkinsonism
Objective: The aim of the present study was to develop and evaluate the neuroprotective effects of resveratrol (RV) using chitosan glutamate nanoparticles (RV-CG-NPs) in a…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.