Investigating the cellular role of LRRK2 in the immune system
Objective: The objective of this project is to investigate the effect of Leucine Rich-Repeat Kinase 2 (LRRK2) dysfunction in the signalling mechanisms in macrophages and…Postural alterations in patients with Progressive Supranuclear Palsy
Objective: Biomechanical assessment of postural imbalance in patients with Progressive Supranuclear Palsy (PSP) Background: PSP is a neurodegenerative disease characterized by early impairment of balance…Cortical FDG-PET patterns predict long-term motor progression and disability milestones in Parkinson’s disease
Objective: To evaluate the accuracy of single-subject FDG-PET in predicting motor and cognitive long-term progression in Parkinson's disease Background: The progression of Parkinson's disease is…Risk of Parkinson’s in idiopathic anosmia
Objective: To identify markers of increased risk of Parkinson’s in a cohort of individuals with idiopathic anosmia Background: Smell loss (anosmia) is a common finding…Evaluation of Clinical Peculiarities of Violations of Vertical Vision in Patients with Parkinson’s Disease
Objective: To study vertical oculomotor reflexes(VOR) and the state of the functional system "eyelid" in patients with Parkinson's disease. Background: Parkinson's disease (PD) is a common…Postural instability secondary to hypoxic injury to the bilateral globus pallidi
Objective: To describe a case of post-hypoxic postural instability associated with bilateral internal globus pallidi (GP) infarcts. Background: A variety of movement disorders, including parkinsonism,…A First in Human Study of PBT434, a Novel Small Molecule Inhibitor of Alpha-Synuclein Aggregation
Objective: To evaluate the safety, tolerability and pharmacokinetics of PBT434 in healthy volunteers. Background: PBT434 is a novel, small molecule inhibitor of alpha-synuclein aggregation. In…Neuroprotective effect of crocus sativus in lead-induced dopaminergic neurotoxicity in Meriones shawi: A possible link with Parkinson’s disease
Objective: In this study, we have evaluated, in one hand, the neurotoxic effect of Pb (25 mg / kg B.W i.p) for three consecutive days…Association between quality of life and physical functions in patients with idiopathic Parkinson’s disease
Objective: The aim was to investigate the association between health-related quality of life and physical functions in the patients with idiopathic Parkinson's disease (PD). Background:…Computing algorithms can detect bradykinesia from smartphone videos
Objective: To investigate whether computer vision algorithms can detect bradykinesia using standard smartphone video alone. Background: Bradykinesia is the core clinical feature of Parkinson’s disease…
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